Palabras clave
candidosis oral, terapia local
Cómo citar
Valoración del tratamiento local de la candidosis oral: Correlación etiológica. (2011). Odontoestomatología, 13(18), 66-75. https://odon.edu.uy/ojs/index.php/ode/article/view/162
Resumen
La candidosis oral es una infección oportunista causada por hongos del género Candida. En los últimos años se ha observado un significativo incremento de la incidencia de las infecciones micóticas. Objetivos. Reconocer las formas clínicas que se observan en los pacientes que concurren a la Clínica de Estomatología de la Facultad de Odontología de la Universidad de la República. Evaluar la eficacia de la terapia local. Establecer la relación entre el tiempo promedio de curación y los factores predisponentes observados. Metodología. Se diagnosticó candidosis oral en 51 pacientes. Se implementó el tratamiento antimicótico tópico, corrección de los factores predisponentes y el régimen de controles clínicos. Resultados. Edad promedio: 50 años, localización prevalente paladar, forma clínica: 54% crónica eritematosa, el 73% de los pacientes curaron entre 14 y 21 días, sólo un 26% necesitó más de 21 días. Conclusiones. Se realiza un primer estudio nacional sobre candidosis oral basado en el diagnóstico clínico, apoyado por el laboratorio microbiológico y histopatológico. Se mostró el índice de respuesta a la terapia local y se confirmó la necesidad de tratamiento más prolongado en el subgrupo de pacientes fumadores.
Referencias
Ruping M, Vebreschild H, Cornely H. Patients at high risk of invasive fungal infections: when and how to treat. Drugs 2008;68:1941 - 1962
Fotos P, Vincent S. Oral candidosis. Oral Surg Oral Med Oral Pathol 1992;74: 41- 49
Samaranayake LP. Nutricional factors and oral candidosis. J. Oral Pathol 1986;15:61 - 65
Guggenheimer J, Moore P, Rossier K, Myers D, Mongelluzzo M. Insulin-dependent diabete mellitus and oral soft tissue pathologies. Prevalence and characteristics of candida and candidal lesions. Oral Surg Oral Med Oral Pathol Oral Radiol Endod. 2000;89:570 – 576
Epstein JB, Hancock P, Nantel S. Oral candidiasis in hematopoietic cell transplantation patients: an outcome – based analysis. Oral Surg Oral Med Oral Pathol Oral Radiol Endod. 2003;96:154 – 163
Terai H, Shimahara M. Cheilitis as a variation of Candida-associated lesions. Oral Diseases 2006;12:349-353
Williams D, Kuriyama T, Silva S, MalicS, Lewis M. Candida biofilms and oral candidosis: treatment and prevention. Periodontology 2000. 2011;15:250 – 265
Samaranayake LP. Oral candidosis. London: Wright, 1990: 185 – 199
Weerasuriya N, Snape J. Oesophageal candidiasis in ederly patients: risk factors, prevention and management. Drugs aging 2008; 25:119-130
Holmstrup P, Axéll T. Classfication and clinical manifestations of oral yeast infections. Acta Odontol. Scand 1990;48:57-59
Sitheeque M, Samaranayake LP. Chronic hyperplastic candidosis (candida- leukoplakia). Crit Rev Oral Biol Med 2003;14:253 – 267
Soysa N, Ellepola A. The impact of cigarette/ tobacco smoking on oral candidosis: an overview. Oral Diseases 2005;11:268-273
Denture stomatitis: a role for Candida biofilms. Oral Surg Oral Med Oral Oral Radiol Endod.2004;98:53 – 59
Barbeau J, Séguin J, Goulet J. Reassesssing the presence of Candida albicans in denture – related stomatitis. Oral Surg Oral Med Oral Oral Radiol Endod 2003;95:51 – 59
Smith a, Robertson D, Tang M, Jackson M, Mackensie D. Staphylococcus aureus in the oral cavity: a three year retrospective analysis of clinical laboratory data.Br Dent J 2003;195:701 – 703
Samaranayake L, Keung W, Jin L. Oral mucosal fungal infections. Periodontology 2000. 2009;49:39-59
Lilic D, Cant A, Abinun M, Calvert J, Spickett G. Chronic mucocutaneous candidiasis. Cin Exp Immunol 1996;105:205 – 212
Pizzo G,Guiliana G.Antifungal activity of chlorhexidine containing mouthrinses. Minerva Stomatologica 1998;47:665-671
Baillie G, Douglas L. Matrix polymers of Candida biofilms and their possible role in resistance to antifungal agents. J Antimicrob Chemother 2000;46:397 – 403
Baillie G, Douglas L. Effect of growth rate on resistance of candida albicans biofi lms to antifungal agents. J Antimicrob Chemother 1998;42:1900 – 1905
Al-Fattani M, Douglas L. Biofi lm matrix of Candida albicans and Candida tropicalis: chemical composition and role in drug resistance. J Med Microbiol 2006;55:9991008
Ogle O, Ofogile F. The pharmacology of topical agents. Oral and Maxillofacial Surgery Clinics of North America. 2001;13:119 – 129
Ellepola A, Samaranayake L. Antimycotic agents in oral candidosis: an overview. Treatment of oral candidosis. Dental Update. 2000;27:165 - 174
Cardozo E, Pardi G, Perrone M, Salazar E. Estudio de la eficacia del Miconazol tópico en pacientes con estomatitis subprotésica. Acta Odontol Venez. 2000;39:45- 53
Chimenos E, Puy D, López J. Fármacos antifúngicos utilizados en el tratamiento de las micosis. Medicina Oral 1998;3:78-90
Mccullough M , Savage N. Oral candidosis and therapeutic use of antifungal agents in dentistry. Australian dental Journal Medications Supplement. 2005;50:36-39
Balleste R., Arteta Z, Fernández N. Evaluación del medio cromógeno CHROMagar CandidaTM para la identificación de levaduras de interés médico. Rev Med Uruguay 2005;21:186-193
Papone V, Morteo G.Prevalencia de Candida spp en la cavidad oral de una población de adultos mayores en Uruguay. ActasOdontológicas, 2009; VI, Nª1: 5-10.
Kadir T, Pisiriciler R, Akyüz S, Emekli N, Ipbüker A. Mycological and cytological examination of oral candidal carriage in diabetic patients and non diabetic control subjects: thorough analysis of local aetiologic and systemic factors. J. Oral Rehabil. 2002; 29(5): 452-457.
Williams D, Lewis M. Pathogenesis and treatment of oral candidosis. J Oral Microbiol. 2011, 3:5771-DOI:10.3402/jom.v3i0.5771
Santos VR, Gomes RT, de Mesquita RA, de Moura MD, França EC, de agiar EG, Naves MD, Abreu JA, Abreu SR. Effi cacy of Brazilian propolis gel for the management of denture stomatitis: a pilot study. Phytother Res. 2008; 22 (11):1544-7
McCullough M, Savage N. Oral candidosis and the therapeutic use of antifungal agents in dentistry. Aust Dent J. 2005; 50(2): 36-39.
Bensaudoun R, Daoud J, Gourmet R, Rosikon A. Comparison of the efficacy and safety of miconazole 50-mg mucoadhesive buccal tablets with miconazole 500-mg gel in the treatment of oropharingeal candidiasis: a prospective, randomized, single-blind, multicenter, comparative, phase III trial in patients treated with radiotherapy for head and neck cancer. Cancer. 2008; 112(1): 204-211.
Zaremba M, Daniluk T, Rozkiewicz D, Kielko A. Incidence rate of Candida species in the oral cavity of middle-aged and elderly subjects. Adv Med Sci.2006; 51: 233-236.
Thaweboon S, Thaweboon B, Srithavaj T. Oral colonization of Candida species in patients receiving radiotherapy in the head and neck area. Quintessence Int. 2008; 39(2): 52-57.
Coco B, Bagg J, Cross L, Ramage G. Mixed Candida albicans and Candida glabata populations associated with the pathogenesis of denture stomatitis. Oral Microbiol Inmunol. 2008: 23(5): 377-383.
Campisi G. Panzarella V, Matranga D, Calvino F. Risk factors of oral candidosis: a twofold approach of study by fuzzy logia and traditional statistic. Arch. Oral Biol 2008; 53: 388-397.
Samaranayake L, JinL. Oral mucosal fungal infections. Periodontol. 2000-2009; 49: 39-59
Soysa N, Ellepola A. The impact of cigarette/ tabacco smoking on oral candidosis: an overview. Oral Diseases.2005; 11; 268-273
Baboni F, Samaranayake L, Barp D, Isidoro A. Enhacement of Candida albicans virulence after exposition to cigarette mainstream smoke. Mycopathologia. 2009; 160(54): 227-235.
Fotos P, Vincent S. Oral candidosis. Oral Surg Oral Med Oral Pathol 1992;74: 41- 49
Samaranayake LP. Nutricional factors and oral candidosis. J. Oral Pathol 1986;15:61 - 65
Guggenheimer J, Moore P, Rossier K, Myers D, Mongelluzzo M. Insulin-dependent diabete mellitus and oral soft tissue pathologies. Prevalence and characteristics of candida and candidal lesions. Oral Surg Oral Med Oral Pathol Oral Radiol Endod. 2000;89:570 – 576
Epstein JB, Hancock P, Nantel S. Oral candidiasis in hematopoietic cell transplantation patients: an outcome – based analysis. Oral Surg Oral Med Oral Pathol Oral Radiol Endod. 2003;96:154 – 163
Terai H, Shimahara M. Cheilitis as a variation of Candida-associated lesions. Oral Diseases 2006;12:349-353
Williams D, Kuriyama T, Silva S, MalicS, Lewis M. Candida biofilms and oral candidosis: treatment and prevention. Periodontology 2000. 2011;15:250 – 265
Samaranayake LP. Oral candidosis. London: Wright, 1990: 185 – 199
Weerasuriya N, Snape J. Oesophageal candidiasis in ederly patients: risk factors, prevention and management. Drugs aging 2008; 25:119-130
Holmstrup P, Axéll T. Classfication and clinical manifestations of oral yeast infections. Acta Odontol. Scand 1990;48:57-59
Sitheeque M, Samaranayake LP. Chronic hyperplastic candidosis (candida- leukoplakia). Crit Rev Oral Biol Med 2003;14:253 – 267
Soysa N, Ellepola A. The impact of cigarette/ tobacco smoking on oral candidosis: an overview. Oral Diseases 2005;11:268-273
Denture stomatitis: a role for Candida biofilms. Oral Surg Oral Med Oral Oral Radiol Endod.2004;98:53 – 59
Barbeau J, Séguin J, Goulet J. Reassesssing the presence of Candida albicans in denture – related stomatitis. Oral Surg Oral Med Oral Oral Radiol Endod 2003;95:51 – 59
Smith a, Robertson D, Tang M, Jackson M, Mackensie D. Staphylococcus aureus in the oral cavity: a three year retrospective analysis of clinical laboratory data.Br Dent J 2003;195:701 – 703
Samaranayake L, Keung W, Jin L. Oral mucosal fungal infections. Periodontology 2000. 2009;49:39-59
Lilic D, Cant A, Abinun M, Calvert J, Spickett G. Chronic mucocutaneous candidiasis. Cin Exp Immunol 1996;105:205 – 212
Pizzo G,Guiliana G.Antifungal activity of chlorhexidine containing mouthrinses. Minerva Stomatologica 1998;47:665-671
Baillie G, Douglas L. Matrix polymers of Candida biofilms and their possible role in resistance to antifungal agents. J Antimicrob Chemother 2000;46:397 – 403
Baillie G, Douglas L. Effect of growth rate on resistance of candida albicans biofi lms to antifungal agents. J Antimicrob Chemother 1998;42:1900 – 1905
Al-Fattani M, Douglas L. Biofi lm matrix of Candida albicans and Candida tropicalis: chemical composition and role in drug resistance. J Med Microbiol 2006;55:9991008
Ogle O, Ofogile F. The pharmacology of topical agents. Oral and Maxillofacial Surgery Clinics of North America. 2001;13:119 – 129
Ellepola A, Samaranayake L. Antimycotic agents in oral candidosis: an overview. Treatment of oral candidosis. Dental Update. 2000;27:165 - 174
Cardozo E, Pardi G, Perrone M, Salazar E. Estudio de la eficacia del Miconazol tópico en pacientes con estomatitis subprotésica. Acta Odontol Venez. 2000;39:45- 53
Chimenos E, Puy D, López J. Fármacos antifúngicos utilizados en el tratamiento de las micosis. Medicina Oral 1998;3:78-90
Mccullough M , Savage N. Oral candidosis and therapeutic use of antifungal agents in dentistry. Australian dental Journal Medications Supplement. 2005;50:36-39
Balleste R., Arteta Z, Fernández N. Evaluación del medio cromógeno CHROMagar CandidaTM para la identificación de levaduras de interés médico. Rev Med Uruguay 2005;21:186-193
Papone V, Morteo G.Prevalencia de Candida spp en la cavidad oral de una población de adultos mayores en Uruguay. ActasOdontológicas, 2009; VI, Nª1: 5-10.
Kadir T, Pisiriciler R, Akyüz S, Emekli N, Ipbüker A. Mycological and cytological examination of oral candidal carriage in diabetic patients and non diabetic control subjects: thorough analysis of local aetiologic and systemic factors. J. Oral Rehabil. 2002; 29(5): 452-457.
Williams D, Lewis M. Pathogenesis and treatment of oral candidosis. J Oral Microbiol. 2011, 3:5771-DOI:10.3402/jom.v3i0.5771
Santos VR, Gomes RT, de Mesquita RA, de Moura MD, França EC, de agiar EG, Naves MD, Abreu JA, Abreu SR. Effi cacy of Brazilian propolis gel for the management of denture stomatitis: a pilot study. Phytother Res. 2008; 22 (11):1544-7
McCullough M, Savage N. Oral candidosis and the therapeutic use of antifungal agents in dentistry. Aust Dent J. 2005; 50(2): 36-39.
Bensaudoun R, Daoud J, Gourmet R, Rosikon A. Comparison of the efficacy and safety of miconazole 50-mg mucoadhesive buccal tablets with miconazole 500-mg gel in the treatment of oropharingeal candidiasis: a prospective, randomized, single-blind, multicenter, comparative, phase III trial in patients treated with radiotherapy for head and neck cancer. Cancer. 2008; 112(1): 204-211.
Zaremba M, Daniluk T, Rozkiewicz D, Kielko A. Incidence rate of Candida species in the oral cavity of middle-aged and elderly subjects. Adv Med Sci.2006; 51: 233-236.
Thaweboon S, Thaweboon B, Srithavaj T. Oral colonization of Candida species in patients receiving radiotherapy in the head and neck area. Quintessence Int. 2008; 39(2): 52-57.
Coco B, Bagg J, Cross L, Ramage G. Mixed Candida albicans and Candida glabata populations associated with the pathogenesis of denture stomatitis. Oral Microbiol Inmunol. 2008: 23(5): 377-383.
Campisi G. Panzarella V, Matranga D, Calvino F. Risk factors of oral candidosis: a twofold approach of study by fuzzy logia and traditional statistic. Arch. Oral Biol 2008; 53: 388-397.
Samaranayake L, JinL. Oral mucosal fungal infections. Periodontol. 2000-2009; 49: 39-59
Soysa N, Ellepola A. The impact of cigarette/ tabacco smoking on oral candidosis: an overview. Oral Diseases.2005; 11; 268-273
Baboni F, Samaranayake L, Barp D, Isidoro A. Enhacement of Candida albicans virulence after exposition to cigarette mainstream smoke. Mycopathologia. 2009; 160(54): 227-235.