Palabras clave
Carcinoma de células escamosas de cabeza y cuello, Epidemiología y Sobrevida.
Cómo citar
Perfil del Carcinoma Oral de Células Escamosas en el Laboratorio de Anatomía Patológica de la Facultad de Odontología de la Universidad de la República, período 1982-2015. (2020). Odontoestomatología, 22(36), 34-43. https://doi.org/10.22592/ode2020n36a5
Resumen
El Carcinoma oral de células escamosas es la patología oral maligna más frecuente, asociada principalmente al tabaco, alcohol y virus del papiloma humano.
El objetivo del estudio fue determinar el perfil de dicha patología, en el Laboratorio de Anatomía Patológica de la Facultad de Odontología de la Universidad de la República entre 1982-2015. Se realizó un estudio retrospectivo, transversal, analítico. Análisis estadístico usando el modelo de Cox, el test exacto de Fisher y el método de Kaplan Meier. Con 207 casos el 59,9% fueron hombres y el 98.5% mayores de 40 años. Localizándose preferentemente en la lengua, con predominio de los carcinomas histopatologicamente bien y moderadamente diferenciados. Se encontró asociación entre el grado histopatológico, género y edad; con un tiempo medio de sobrevida de 2.36 años y una tasa de sobrevida del 43% a los 5 años. El estudio permitió conocer dicha patología en un servicio de referencia y generar una base de datos para posteriores estudios.
Referencias
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2. Torre LA, Bray F, Siegel RL, Ferlay J, Lortet- Tieulent J, Jemal A. Global cancer statistics, 2012. CA Cancer J Clin. 2015; 65 (2): 87–108.
3. Warnakulasuriya S. Global epidemiology of oral and oropharyngeal cancer. Oral Oncology. 2009; 45: 309-316.
4. Neville, Brad W. Patologia oral e maxilofacial. 4. ed. Rio de Janeiro: Elsevier, 2016. 912 p. ISBN: 978-85-352-6564-4
5. Licitra L, Locati LD, Bossi P, Cantù G. Head and neck tumors other than squamous cell carcinoma. Curr Opin Oncol. 2004; 16 (3): 236– 41.
6. Johnson NW, Jayasekara P, Amarasinghe AAHK. Squamous cell carcinoma and precursor lesions of the oral cavity: epidemiology and etiology. Periodontol 2000. 2011 ; 57 (1): 19– 37.
7. Barnes L, Eveson JW, Reichart P, Sidransky D. World Health Organization classification of tumours: Pathology & genetics Head and Neck tumours. International Agency for Research on Cancer, Lyon, France 2005; 168-175.
8. El-Naggar AK, Chan JKC, Rubin Grandis J, Takata T, Slootweg PJ. WHO classification of head and neck tumours. International Agency for Research on Cancer. 4th ed. 2017.
9. Kang H, Kiess A, Chung C. Emerging biomarkers in head and neck cancer in the era of genomics. Nat Rev Clin Oncol. 2015; 12: 11–26.
10. Miguel Cruz PA, Niño Peña A, Batista Marrero K, Miguel-Soca PE. Factores de riesgo de cáncer bucal. Rev Cubana Estomatol. 2016; 53 (3): 128–45.
11. Jiang X, Wu J, Jiexue Wang RH. Tobacco and oral squamous cell carcinoma: A review of carcinogenic pathways. Tob Induc Dis. 2019; 17.
12. Auluck A, Hislop G, Bajdik C, Poh C, Zhang L RM. Trends in oro- pharyngeal and oral cavity cancer incidence of human papillomavirus (HPV)-related and HPV-unrelated sites in a multicultural population: the British Columbia experience. Cancer. 2010; 116: 2635–2644.
13. Young D, Xiao CC, Murphy B, Moore M, Fakhry C, Day TA. Increase in head and neck cancer in younger patients due to human papillomavirus (HPV). Oral Oncology. 2015; 51.
14. Ferlay J, Colombet M, Soerjomataram I, Mathers C, Parkin DM, Piñeros M, Znaor A, Bray F. Estimating the global cancer incidence and mortality in 2018: GLOBOCAN sources and methods. Int J Cancer. 2018. https: //doi. org/10.1002/ijc.31937
15. Comisión Honoraria de Lucha Contra el Cáncer. Situacion Epidemiologica del Uruguay en relacion al Cancer. Regist Nac del Cáncer, Com Honor Lucha Contra el Cáncer. 2019; 1–61.
16. Lopes KM,Souza JA, Lacerda de Souza L, Akiko ML, Guimarão DM, Pontes HA. La proteína Ki-67 predice la supervivencia en las células de carcinoma escamoso oral: un estudio inmunohistoquímico. Braz. res oral. 2017; 31: e66.
17. Majumdar B, Shankargouda P, Sachin CS, Gargi SS and Roopa SR. Clinico-pathological prognosticators in oral squamous cell carcinoma: An update Translational. Research in Oral Oncology. 2017; (2): 1–14.
18. Mamelle G, Pampurik J, Luboinski B, Lancar R, Lusinchi A, Bosq J. Lymph node prognostic factors in head and neck squamous cell carcinomas. Am J Surg. 1994; 168 (5): 494–8.
19. Oliveira MLC, Wagner VP, Sant’ana Filho M, Carrard VC, Hugo FN, Martins MD. A 10- year analysis of the oral squamous cell carcinoma profile in patients from public health centers in Uruguay. Braz Oral Res. 2015; 29 (1): 1–8.
20. Barrios E, Garau M. Cáncer: magnitud del problema en el mundo y en Uruguay, aspectos epidemiológicos. An la Fac Med. 2017; 4 (1): 04-66.
21. Barrios E, Garau M, Alonso R, Musetti C. IV atlas de incidencia del cancer en el Uruguay. Registro Nacional de Cáncer, Comisión Honoraria de lucha contra el Cáncer, 2014.
22. Ferlay J, Soerjomataram I, Dikshit R, Eser S, Mathers C, Rebelo M, et al. Cancer incidence and mortality worldwide: Sources, methods and major patterns in GLOBOCAN 2012. Int J Cancer. 2015; 136 (5).
23. Patel RS, Clark JR, Dirven R, Wyten R, Gao K, O’Brien CJ. Prognostic factors in the surgical treatment of patients with oral carcinoma. ANZ J Surg. 2009 Jan; 79(1–2): 19–22.
24. Mamelle G, Pampurik J, Luboinski B, Lancar R, Lusinchi A, Bosq J. Lymph node prognostic factors in head and neck squamous cell carcinomas. Am J Surg. 1994; 168(5): 494–8.
25. Lydiatt WM, Patel SG, O’Sullivan B, Brandwein MS, Ridge JA, Migliacci JC, et al. Head and neck cancers-major changes in the American Joint Committee on cancer eighth edition cancer staging manual. CA Cancer J Clin. 2017; 67(2): 122-37.
26. Roberto De Oliveira L, Ribeiro-Silva A, Zucoloto S. Perfil da incidência e da sobrevida de pacientes com carcinoma epidermóide oral em uma população brasileira Incidence and survival profile of patients with oral squamous cell carcinoma in a Brazilian population. J Bras Patol Med Lab. 2006; 42 (5): 385–92.
27. Ferlay J, Colombet M, Soerjomataram I, Mathers C, Parkin DM, Piñeros M, A Znaor Estimating the global cancer incidence and mortality in 2018: GLOBOCAN sources and methods. Int J Cancer. 2018; 144 (8): 1941- 1953
28. Estimativa 2018: incidência de câncer no Brasil / Instituto Nacional de Câncer José Alencar Gomes da Silva. In 2017. Ministério da saúde, Instituto Nacional de Câncer José Alencar Gomes da Silva (INCA).
29. Chan MH, Wang F, Mang W kong, Tse LA. Sex Differences in Time Trends on Incidence Rates of Oropharyngeal and Oral Cavity Cancers in Hong Kong. Ann Otol Rhinol Laryngol. 2018; 127 (12): 895–902.
30. Momares B, Contreras G, Martínez B, Ávalos N, Carmona L. Sobrevida en Carcinoma Espinocelular de mucosa oral: análisis de 161 pacientes. Rev Chil Cir. 2014; 66 (6): 568–76.
31. Shridhar K, Rajaraman P, Koyande S, Parikh PM, Chaturvedi P, Dhillon PK, Rajesh Dikshit P. Trends in mouth cancer incidence in Mumbai, India (1995-2009): An age-period-cohort analysis. Trends mouth cancer Incid Mumbai. 2016; 42 (2016): 66-71.
32. Salgado-Ramíre B, Rivera-Martínez CG, Altamirano-Díaz I, Salgado-Ramírez B. Frecuencia de carcinoma de cavidad oral en un Hospital de tercer nivel. Rev Sanid Milit Mex. 2014; 68 (3): 172–6.
33. Alvarez Arias D, Munyo Estefan A, Borche G, Rodríguez Sande V, Cuello M. Cáncer de cabeza y cuello en Uruguay. Análisis de sobrevida en dos centros de referencia. Rev Méd Urug. 2018; 34 (1): 21–8.
34. Beovide Cortegoso AV, Koerich Laureano N, Dutra da Silva A, Krebs Danilevicz C, Sellinger Magnusson A, et al. Cell proliferation markers at the invasive tumor front of oral squamous cell carcinoma: comparative analysis in relation to clinicopathological parameters of patients. J Appl Oral Sci. 2017; 25 (3): 318–23.
35. Brandizzi D, Gandolfo M, Velazco ML, Cabrini RL, Lanfranchi HE. Clinical features and evolution of oral cancer: A study of 274 cases in Buenos Aires, Argentina. Med Oral Patol Oral Cir Bucal. 2008; 13 (9): E544-8.
36. Siriwardena BS, Tilakaratne A, Amaratunga EAPD, Tilakaratne WM. Demographic, aetiological and survival differences of oral squamous cell carcinoma in the young and the old in Sri Lanka. Oral Oncol. 2006; 42 (8): 831–6.
37. Muradás Girardi F, Fuga GR, Callai T, Fernandes Bianchi M, Girardi FM. Histopatological differences between genders in patients witH oral squamous cell carcinoma. Clin Biomed Res. 2017; 37 (3): 147–50.
38. Jie W, Bai J, Li B. Clinicopathologic Analysis of Oral Squamous Cell Carcinoma After 125 I Interstitial Brachytherapy. Technol Cancer Res Treatmen. 2018; 17: 1–5.
39. Saira, Fiaz Khan M, Rauf Khattak M, Rawail A, Malik S. Epidemiological and clinical correlates of oral squamous cell carcinoma in patients from north-west Pakistan. J Pak Med Assoc. 2019; 69 (8): 1074-1078.
40. Gul H, Asif F, Ghaffar I, Anwar MA, Tayyab MA, Kashif M. Epidemiology and pathological trends in oral squamous cell carcinoma in a local tertiary care hospital. Int J Community Med Public Heal. 2017; 4 (12): 4440.
41. Leite AA, Leonel ACL da S, de Castro JFL, Carvalho EJ de A, Vargas PA, Kowalski LP, da Cruz Perez DE. Oral squamous cell carcinoma: A clinicopathological study on 194 cases in northeastern Brazil. A cross-sectional retrospective study. Sao Paulo Med J. 2018; 136 (2): 165–9.
42. Álvarez Martínez E, Preciado A, Montoya Fernández SA, Jiménez Gómez R, Posada A. Características clínico-histopatológicas del carcinoma escamocelular bucal, Colombia. Rev Cubana Estomatol. 2010; 47 (1): 81-95.
43. Bórquez PM, Capdeville FF, Madrid AM, Veloso MO, Cárcamo MP. Sobrevida global y por estadíos de 137 pacientes con cáncer intraoral. Experiencia del Instituto Nacional del Cáncer. Rev. Chilena de Cirugía. 2011; 63 (4): 351- 355.
44. Bonfante GM, Machado CJ, Souza PEA, Andrade EIG, Acurcio F de A, Cherchiglia ML. Sobrevida de cinco anos e fatores associados ao câncer de boca para pacientes em tratamento oncológico ambulatorial pelo Sistema Único de Saúde, Brasil. Cad Saude Publica. 2014; 30 (5): 983–97.
45. Brandizzi D, Gandolfo M, Velazco ML CR, Lanfranchi HE. Clinical features and evolution of oral cancer: a study of 274 cases in Buenos Aires, Argentina. Med Oral Patol Oral Cir Bucal. 2008; 13: E544-8.
2. Torre LA, Bray F, Siegel RL, Ferlay J, Lortet- Tieulent J, Jemal A. Global cancer statistics, 2012. CA Cancer J Clin. 2015; 65 (2): 87–108.
3. Warnakulasuriya S. Global epidemiology of oral and oropharyngeal cancer. Oral Oncology. 2009; 45: 309-316.
4. Neville, Brad W. Patologia oral e maxilofacial. 4. ed. Rio de Janeiro: Elsevier, 2016. 912 p. ISBN: 978-85-352-6564-4
5. Licitra L, Locati LD, Bossi P, Cantù G. Head and neck tumors other than squamous cell carcinoma. Curr Opin Oncol. 2004; 16 (3): 236– 41.
6. Johnson NW, Jayasekara P, Amarasinghe AAHK. Squamous cell carcinoma and precursor lesions of the oral cavity: epidemiology and etiology. Periodontol 2000. 2011 ; 57 (1): 19– 37.
7. Barnes L, Eveson JW, Reichart P, Sidransky D. World Health Organization classification of tumours: Pathology & genetics Head and Neck tumours. International Agency for Research on Cancer, Lyon, France 2005; 168-175.
8. El-Naggar AK, Chan JKC, Rubin Grandis J, Takata T, Slootweg PJ. WHO classification of head and neck tumours. International Agency for Research on Cancer. 4th ed. 2017.
9. Kang H, Kiess A, Chung C. Emerging biomarkers in head and neck cancer in the era of genomics. Nat Rev Clin Oncol. 2015; 12: 11–26.
10. Miguel Cruz PA, Niño Peña A, Batista Marrero K, Miguel-Soca PE. Factores de riesgo de cáncer bucal. Rev Cubana Estomatol. 2016; 53 (3): 128–45.
11. Jiang X, Wu J, Jiexue Wang RH. Tobacco and oral squamous cell carcinoma: A review of carcinogenic pathways. Tob Induc Dis. 2019; 17.
12. Auluck A, Hislop G, Bajdik C, Poh C, Zhang L RM. Trends in oro- pharyngeal and oral cavity cancer incidence of human papillomavirus (HPV)-related and HPV-unrelated sites in a multicultural population: the British Columbia experience. Cancer. 2010; 116: 2635–2644.
13. Young D, Xiao CC, Murphy B, Moore M, Fakhry C, Day TA. Increase in head and neck cancer in younger patients due to human papillomavirus (HPV). Oral Oncology. 2015; 51.
14. Ferlay J, Colombet M, Soerjomataram I, Mathers C, Parkin DM, Piñeros M, Znaor A, Bray F. Estimating the global cancer incidence and mortality in 2018: GLOBOCAN sources and methods. Int J Cancer. 2018. https: //doi. org/10.1002/ijc.31937
15. Comisión Honoraria de Lucha Contra el Cáncer. Situacion Epidemiologica del Uruguay en relacion al Cancer. Regist Nac del Cáncer, Com Honor Lucha Contra el Cáncer. 2019; 1–61.
16. Lopes KM,Souza JA, Lacerda de Souza L, Akiko ML, Guimarão DM, Pontes HA. La proteína Ki-67 predice la supervivencia en las células de carcinoma escamoso oral: un estudio inmunohistoquímico. Braz. res oral. 2017; 31: e66.
17. Majumdar B, Shankargouda P, Sachin CS, Gargi SS and Roopa SR. Clinico-pathological prognosticators in oral squamous cell carcinoma: An update Translational. Research in Oral Oncology. 2017; (2): 1–14.
18. Mamelle G, Pampurik J, Luboinski B, Lancar R, Lusinchi A, Bosq J. Lymph node prognostic factors in head and neck squamous cell carcinomas. Am J Surg. 1994; 168 (5): 494–8.
19. Oliveira MLC, Wagner VP, Sant’ana Filho M, Carrard VC, Hugo FN, Martins MD. A 10- year analysis of the oral squamous cell carcinoma profile in patients from public health centers in Uruguay. Braz Oral Res. 2015; 29 (1): 1–8.
20. Barrios E, Garau M. Cáncer: magnitud del problema en el mundo y en Uruguay, aspectos epidemiológicos. An la Fac Med. 2017; 4 (1): 04-66.
21. Barrios E, Garau M, Alonso R, Musetti C. IV atlas de incidencia del cancer en el Uruguay. Registro Nacional de Cáncer, Comisión Honoraria de lucha contra el Cáncer, 2014.
22. Ferlay J, Soerjomataram I, Dikshit R, Eser S, Mathers C, Rebelo M, et al. Cancer incidence and mortality worldwide: Sources, methods and major patterns in GLOBOCAN 2012. Int J Cancer. 2015; 136 (5).
23. Patel RS, Clark JR, Dirven R, Wyten R, Gao K, O’Brien CJ. Prognostic factors in the surgical treatment of patients with oral carcinoma. ANZ J Surg. 2009 Jan; 79(1–2): 19–22.
24. Mamelle G, Pampurik J, Luboinski B, Lancar R, Lusinchi A, Bosq J. Lymph node prognostic factors in head and neck squamous cell carcinomas. Am J Surg. 1994; 168(5): 494–8.
25. Lydiatt WM, Patel SG, O’Sullivan B, Brandwein MS, Ridge JA, Migliacci JC, et al. Head and neck cancers-major changes in the American Joint Committee on cancer eighth edition cancer staging manual. CA Cancer J Clin. 2017; 67(2): 122-37.
26. Roberto De Oliveira L, Ribeiro-Silva A, Zucoloto S. Perfil da incidência e da sobrevida de pacientes com carcinoma epidermóide oral em uma população brasileira Incidence and survival profile of patients with oral squamous cell carcinoma in a Brazilian population. J Bras Patol Med Lab. 2006; 42 (5): 385–92.
27. Ferlay J, Colombet M, Soerjomataram I, Mathers C, Parkin DM, Piñeros M, A Znaor Estimating the global cancer incidence and mortality in 2018: GLOBOCAN sources and methods. Int J Cancer. 2018; 144 (8): 1941- 1953
28. Estimativa 2018: incidência de câncer no Brasil / Instituto Nacional de Câncer José Alencar Gomes da Silva. In 2017. Ministério da saúde, Instituto Nacional de Câncer José Alencar Gomes da Silva (INCA).
29. Chan MH, Wang F, Mang W kong, Tse LA. Sex Differences in Time Trends on Incidence Rates of Oropharyngeal and Oral Cavity Cancers in Hong Kong. Ann Otol Rhinol Laryngol. 2018; 127 (12): 895–902.
30. Momares B, Contreras G, Martínez B, Ávalos N, Carmona L. Sobrevida en Carcinoma Espinocelular de mucosa oral: análisis de 161 pacientes. Rev Chil Cir. 2014; 66 (6): 568–76.
31. Shridhar K, Rajaraman P, Koyande S, Parikh PM, Chaturvedi P, Dhillon PK, Rajesh Dikshit P. Trends in mouth cancer incidence in Mumbai, India (1995-2009): An age-period-cohort analysis. Trends mouth cancer Incid Mumbai. 2016; 42 (2016): 66-71.
32. Salgado-Ramíre B, Rivera-Martínez CG, Altamirano-Díaz I, Salgado-Ramírez B. Frecuencia de carcinoma de cavidad oral en un Hospital de tercer nivel. Rev Sanid Milit Mex. 2014; 68 (3): 172–6.
33. Alvarez Arias D, Munyo Estefan A, Borche G, Rodríguez Sande V, Cuello M. Cáncer de cabeza y cuello en Uruguay. Análisis de sobrevida en dos centros de referencia. Rev Méd Urug. 2018; 34 (1): 21–8.
34. Beovide Cortegoso AV, Koerich Laureano N, Dutra da Silva A, Krebs Danilevicz C, Sellinger Magnusson A, et al. Cell proliferation markers at the invasive tumor front of oral squamous cell carcinoma: comparative analysis in relation to clinicopathological parameters of patients. J Appl Oral Sci. 2017; 25 (3): 318–23.
35. Brandizzi D, Gandolfo M, Velazco ML, Cabrini RL, Lanfranchi HE. Clinical features and evolution of oral cancer: A study of 274 cases in Buenos Aires, Argentina. Med Oral Patol Oral Cir Bucal. 2008; 13 (9): E544-8.
36. Siriwardena BS, Tilakaratne A, Amaratunga EAPD, Tilakaratne WM. Demographic, aetiological and survival differences of oral squamous cell carcinoma in the young and the old in Sri Lanka. Oral Oncol. 2006; 42 (8): 831–6.
37. Muradás Girardi F, Fuga GR, Callai T, Fernandes Bianchi M, Girardi FM. Histopatological differences between genders in patients witH oral squamous cell carcinoma. Clin Biomed Res. 2017; 37 (3): 147–50.
38. Jie W, Bai J, Li B. Clinicopathologic Analysis of Oral Squamous Cell Carcinoma After 125 I Interstitial Brachytherapy. Technol Cancer Res Treatmen. 2018; 17: 1–5.
39. Saira, Fiaz Khan M, Rauf Khattak M, Rawail A, Malik S. Epidemiological and clinical correlates of oral squamous cell carcinoma in patients from north-west Pakistan. J Pak Med Assoc. 2019; 69 (8): 1074-1078.
40. Gul H, Asif F, Ghaffar I, Anwar MA, Tayyab MA, Kashif M. Epidemiology and pathological trends in oral squamous cell carcinoma in a local tertiary care hospital. Int J Community Med Public Heal. 2017; 4 (12): 4440.
41. Leite AA, Leonel ACL da S, de Castro JFL, Carvalho EJ de A, Vargas PA, Kowalski LP, da Cruz Perez DE. Oral squamous cell carcinoma: A clinicopathological study on 194 cases in northeastern Brazil. A cross-sectional retrospective study. Sao Paulo Med J. 2018; 136 (2): 165–9.
42. Álvarez Martínez E, Preciado A, Montoya Fernández SA, Jiménez Gómez R, Posada A. Características clínico-histopatológicas del carcinoma escamocelular bucal, Colombia. Rev Cubana Estomatol. 2010; 47 (1): 81-95.
43. Bórquez PM, Capdeville FF, Madrid AM, Veloso MO, Cárcamo MP. Sobrevida global y por estadíos de 137 pacientes con cáncer intraoral. Experiencia del Instituto Nacional del Cáncer. Rev. Chilena de Cirugía. 2011; 63 (4): 351- 355.
44. Bonfante GM, Machado CJ, Souza PEA, Andrade EIG, Acurcio F de A, Cherchiglia ML. Sobrevida de cinco anos e fatores associados ao câncer de boca para pacientes em tratamento oncológico ambulatorial pelo Sistema Único de Saúde, Brasil. Cad Saude Publica. 2014; 30 (5): 983–97.
45. Brandizzi D, Gandolfo M, Velazco ML CR, Lanfranchi HE. Clinical features and evolution of oral cancer: a study of 274 cases in Buenos Aires, Argentina. Med Oral Patol Oral Cir Bucal. 2008; 13: E544-8.