Keywords
Immunoglobulin A, Saliva, Dental Caries, Adolescents.
How to Cite
Relación entre la Salud Bucal y la oncentración de Inmunoglobulina A Salival en Adolescentes. (2019). Odontoestomatología, 15(21), 38-45. https://odon.edu.uy/ojs/index.php/ode/article/view/108
Abstract
Objective: the aim of this study was to evaluate the possible relationship between bucal health of adolescents and IgA concentration in saliva. Method: we conducted a cross-sectional study. Te population consisted of individuals of both sexes, without systemic pathologies. All selected patients underwent a complete medical history, caries index, plaque and gingival index. For the dosage of IgA in saliva sample was collected from each patient involved in the research. The technique used for the determination of IgA in saliva, was the radial immunodiffusion (RID). Results: 86% of the sample showed an index decay of 13.17 and 54% showed gingival and plaque indexes of 1.34 and 40.15% respectively. A signifcant inverse correlation was found between salivary IgA and the caries values. Conclusion: saliva may have a modulating influence on the microorganisms involved in caries, through the secretion of IgA.
References
1. Carosella M, Milgram L. Análisis del estado de la salud bucal de una población adolescente. Arch Argent Pediatr 2003;101(6):454-459.
2. Bagherian A, Jafarzadeh A, Rezaeian M, Ahmadi S, Taghi Rezaity M. Comparison of the salivary immunoglobulin concentration levels between children with early
childhood caries and caries free children. Iran J Immunol. 2008;5(4):217-221.
3. Chacón de Petrola MR, Flores ME, Rodríguez S, Valles L, Petrola C, Torres A, et al. Niveles de inmunoglobulina A secretora (IgAs) en saliva en una población
sana del Estado Carabobo (Venezuela) [en línea]. Salus online 2008;8(1):8-16. [Disponible en: http://salus-online.fcs.uc.edu.ve/t1_igas_saliva.pdf] [fecha de acceso: 12 de julio de 2011].
4. Zaldívar Ochoa M. El sistema inmunológico de las mucosas [en línea]. Rev Cubana Med Gen Integr 2002;18(5):352-354. [Disponible en: http://bvs.sld.cu/revistas/
mgi/vol18_5_02/mgi1252002.htm] [fecha de acceso: 18 de octubre de 2011].
5. Slobodianik N, Feliu MS. Valores de referencia de IgA en saliva-Carta al Editor. Acta Bioquim Clín Latinoam 1992; 26(1):101-102.
6. Moragrega JA. Valores de referencia de inmunoglobulina “A” en saliva. Acta Bioquim Clín Latinoam 1996;30(2):141-9.
7. Macrotte H, Lavoie MC. Oral microbial ecology and the role of salivary immunoglobulin A. Microbial Mol Biol Rev. 1998;62:71-109.
8. Shifa S, Muthu MS, Amarlal D, Ratna Prabhu V. Quantiative assessment of IgA levels in the unstimulated whole saliva of caries-free and caries-active children
[en línea]. J Indian Soc Pedod Prev Dent 2008;26:158-6. [Disponible en: http://www.jisppd.com/article.asp?issn=0970-4388;year=2008; volume=26; issue=4;sp
age=158;epage=161;aulast=Shifa] [fecha de acceso: 20 de abril de 2012].
9. Taweboon S, Taweboon B, Nakornchai S, Jitmaitree S. Salivary secretory IgA, pH, flow rates, mutans streptococci and Candida in children with rampant
caries. Southeast Asian J Trop Med Public Health. 2008;39(5):893-9.
10. Benderli Y, Erdilek D, Koray F, Telci A, Turan N. the relation between salivary IgA and caries in renal transplant patients. Oral surg Oral Med Oral Pathol Oral Radiol Endod. 2000;89:588-93.
11. de Farias DG, Bezerra AC. Salivary antibodies, amylase and protein from children with early childhood caries. Clin Oral Investig 2003;7:154-7.
12. Cogulu D, Sabah E, Kutukculer N, Ozkinay F. Evaluation of the relationship between caries indices and salivary secretory IgA, salivary pH, buffering capacity and
flow rate in children with Down’s syndrome. Arch Oral Biol 2006;51:23-8.
13. Camling E, Kohler B. Infection with the bacterium Streptococcus mutans and salivary IgA antibodies in mothers and their children. Arch Oral Biol 1987;32:817-
23.
14. Parkash H, Sharma A, Banerjee U, Sidhu SS, Sundaram KR. Humoral immune response to mutans streptococci associated with dental caries. Natl Med J India
1994;7:263-6.
15. Bratthall D, Serinirach R, Hamberg K, Widerstrom L. Immunoglobulin A reaction to oral streptococci in saliva of subjects with different combinations of caries
and levels of mutans streptococci. Oral Microbiol Immunol 1997;12:212-8.
16. Senpuku H, Miyazaki H, Yoneda S, Yoshihara A, Tada A. A quick statistically accurate diagnosis for caries risk in the elderly.44 Martínez Sandra Elena, Juárez Rolando Pablo, Vila Vilma Graciela, Hormaechea María Inés Clin Lab. 2010; 56(11-12):505-12.
17. Doifode D, Damle SG. Comparison of salivary IgA levels in caries free and caries active children. Int JClin Dent Sci 2011;2:10-4.
18. Bruno B, Pezzini A, Menegazzi M. Salivary levels of immunoglobulin and dental caries in children. Boll Soc Ital Biol Sper 1985;61:381-6.
19. Al Amoudi N, Al Shukairy H, Hanno A. A comparative study of the secretory IgA immunoglobulins (s.IgA) in mothers and children with SECC versus a caries free
group children and their mothers. J Clin Pediatr Dent. 2007; 32(1):53-6.
20. Everhart DL, Rothenberg K, Carter WHJr, Klapper B. Te determination of antibody to streptococcus mutans serotypes in saliva for children ages three to seven
years. J Dent Res 1978;57:631-5.
21. Koga-Ito CY, Martins CA, Balducci I, Jorge AO. Correlation among mutans streptococci counts, dental caries, and IgA to Streptococcus mutans in saliva. Braz Oral Res 2004; 18:350-5.
22. Uygun-Can B, Kadir T, Akyüz S. Oral Candidal carriage in children with and without dental caries. Quintessence Int. 2007;38:45-9.
23. Albers R, Antoine JM, Sicard RB, Calder PC , Gleeson M , Lesourd B, et al. Markers to measure immunomodulation in human nutrition intervention studies. Br
J Nut. 2005;94:452–81.
24. Sanui T, Gregory RL. Analysis of Streptococcus mutans bioflm proteins recognized by salivary immunoglobulin A. Oral Microbiol Immunol. 2009; 24(5):361-8.
25. Shah M, Doshi Y, Hirani SH. Concentration of salivary immunoglobulin A, in relation to periodontal disease, plaque, and calculus. Journal of the International
Clinical Dental Research Organization 2010, 2(3):126-129.
26. Ranadheer E, Nayak UA, Reddy NV, Rao VA. Te relationship between salivary IgA levels and dental caries in children [en línea]. Journal of Indian Society of Pedodontics and Preventive Dentistry 2011; 29(2):106-112. [Disponible en: http://www.jisppd.com/article.asp?issn=0970-4388;year= 2011; volume=29;issue=2;s
page=106;epage=112;aulast=Ranadheer] [fecha de acceso: 20 de mayo de 2012].
2. Bagherian A, Jafarzadeh A, Rezaeian M, Ahmadi S, Taghi Rezaity M. Comparison of the salivary immunoglobulin concentration levels between children with early
childhood caries and caries free children. Iran J Immunol. 2008;5(4):217-221.
3. Chacón de Petrola MR, Flores ME, Rodríguez S, Valles L, Petrola C, Torres A, et al. Niveles de inmunoglobulina A secretora (IgAs) en saliva en una población
sana del Estado Carabobo (Venezuela) [en línea]. Salus online 2008;8(1):8-16. [Disponible en: http://salus-online.fcs.uc.edu.ve/t1_igas_saliva.pdf] [fecha de acceso: 12 de julio de 2011].
4. Zaldívar Ochoa M. El sistema inmunológico de las mucosas [en línea]. Rev Cubana Med Gen Integr 2002;18(5):352-354. [Disponible en: http://bvs.sld.cu/revistas/
mgi/vol18_5_02/mgi1252002.htm] [fecha de acceso: 18 de octubre de 2011].
5. Slobodianik N, Feliu MS. Valores de referencia de IgA en saliva-Carta al Editor. Acta Bioquim Clín Latinoam 1992; 26(1):101-102.
6. Moragrega JA. Valores de referencia de inmunoglobulina “A” en saliva. Acta Bioquim Clín Latinoam 1996;30(2):141-9.
7. Macrotte H, Lavoie MC. Oral microbial ecology and the role of salivary immunoglobulin A. Microbial Mol Biol Rev. 1998;62:71-109.
8. Shifa S, Muthu MS, Amarlal D, Ratna Prabhu V. Quantiative assessment of IgA levels in the unstimulated whole saliva of caries-free and caries-active children
[en línea]. J Indian Soc Pedod Prev Dent 2008;26:158-6. [Disponible en: http://www.jisppd.com/article.asp?issn=0970-4388;year=2008; volume=26; issue=4;sp
age=158;epage=161;aulast=Shifa] [fecha de acceso: 20 de abril de 2012].
9. Taweboon S, Taweboon B, Nakornchai S, Jitmaitree S. Salivary secretory IgA, pH, flow rates, mutans streptococci and Candida in children with rampant
caries. Southeast Asian J Trop Med Public Health. 2008;39(5):893-9.
10. Benderli Y, Erdilek D, Koray F, Telci A, Turan N. the relation between salivary IgA and caries in renal transplant patients. Oral surg Oral Med Oral Pathol Oral Radiol Endod. 2000;89:588-93.
11. de Farias DG, Bezerra AC. Salivary antibodies, amylase and protein from children with early childhood caries. Clin Oral Investig 2003;7:154-7.
12. Cogulu D, Sabah E, Kutukculer N, Ozkinay F. Evaluation of the relationship between caries indices and salivary secretory IgA, salivary pH, buffering capacity and
flow rate in children with Down’s syndrome. Arch Oral Biol 2006;51:23-8.
13. Camling E, Kohler B. Infection with the bacterium Streptococcus mutans and salivary IgA antibodies in mothers and their children. Arch Oral Biol 1987;32:817-
23.
14. Parkash H, Sharma A, Banerjee U, Sidhu SS, Sundaram KR. Humoral immune response to mutans streptococci associated with dental caries. Natl Med J India
1994;7:263-6.
15. Bratthall D, Serinirach R, Hamberg K, Widerstrom L. Immunoglobulin A reaction to oral streptococci in saliva of subjects with different combinations of caries
and levels of mutans streptococci. Oral Microbiol Immunol 1997;12:212-8.
16. Senpuku H, Miyazaki H, Yoneda S, Yoshihara A, Tada A. A quick statistically accurate diagnosis for caries risk in the elderly.44 Martínez Sandra Elena, Juárez Rolando Pablo, Vila Vilma Graciela, Hormaechea María Inés Clin Lab. 2010; 56(11-12):505-12.
17. Doifode D, Damle SG. Comparison of salivary IgA levels in caries free and caries active children. Int JClin Dent Sci 2011;2:10-4.
18. Bruno B, Pezzini A, Menegazzi M. Salivary levels of immunoglobulin and dental caries in children. Boll Soc Ital Biol Sper 1985;61:381-6.
19. Al Amoudi N, Al Shukairy H, Hanno A. A comparative study of the secretory IgA immunoglobulins (s.IgA) in mothers and children with SECC versus a caries free
group children and their mothers. J Clin Pediatr Dent. 2007; 32(1):53-6.
20. Everhart DL, Rothenberg K, Carter WHJr, Klapper B. Te determination of antibody to streptococcus mutans serotypes in saliva for children ages three to seven
years. J Dent Res 1978;57:631-5.
21. Koga-Ito CY, Martins CA, Balducci I, Jorge AO. Correlation among mutans streptococci counts, dental caries, and IgA to Streptococcus mutans in saliva. Braz Oral Res 2004; 18:350-5.
22. Uygun-Can B, Kadir T, Akyüz S. Oral Candidal carriage in children with and without dental caries. Quintessence Int. 2007;38:45-9.
23. Albers R, Antoine JM, Sicard RB, Calder PC , Gleeson M , Lesourd B, et al. Markers to measure immunomodulation in human nutrition intervention studies. Br
J Nut. 2005;94:452–81.
24. Sanui T, Gregory RL. Analysis of Streptococcus mutans bioflm proteins recognized by salivary immunoglobulin A. Oral Microbiol Immunol. 2009; 24(5):361-8.
25. Shah M, Doshi Y, Hirani SH. Concentration of salivary immunoglobulin A, in relation to periodontal disease, plaque, and calculus. Journal of the International
Clinical Dental Research Organization 2010, 2(3):126-129.
26. Ranadheer E, Nayak UA, Reddy NV, Rao VA. Te relationship between salivary IgA levels and dental caries in children [en línea]. Journal of Indian Society of Pedodontics and Preventive Dentistry 2011; 29(2):106-112. [Disponible en: http://www.jisppd.com/article.asp?issn=0970-4388;year= 2011; volume=29;issue=2;s
page=106;epage=112;aulast=Ranadheer] [fecha de acceso: 20 de mayo de 2012].