Keywords
Matrix metalloproteinases, extracellular matrix, dentistry.
How to Cite
Metalloproteinases (MMPs) of the extracellular matrix in Dentistry. (2016). Odontoestomatología, 18(28), 20-29. https://odon.edu.uy/ojs/index.php/ode/article/view/140
Abstract
Most body tissues are found in a constant renovation process, modulated by a large number of proteins that induce tissue synthesis and degradation over time. Matrix metalloproteinases (MMPs) are a family of 25 zinc-dependent endopeptidases in charge of the cleavage of the immediate components of the extracellular matrix. Certain MMPs, especially MMP-2 and MMP-9, are related to the development of dental germ as well as odontogenic tumor invasion and proliferation. They are a significant factor in tumor aggressiveness and possible treatments. Moreover, both MMPs participate in the progression of dental caries and apical periodontitis in patients with necrotic pulp. Several periodontal pathogens promote the secretion of both MMP-2 and MMP-9, increasing the destruction of periodontal tissues, which is closely linked to the progression of the disease. High levels of these MMPs are found in patients undergoing orthodontic treatment, not only in the compression side but also on the tension one. This establishes a connection between tooth movement and tissue renovation. This review analyzes MMPs expression and usefulness in different areas of dental science, emphasizing their potential as biomarkers
References
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22. Wolf K, Friedl P. Mapping proteolytic cancer cell-extracellular matrix interfaces. Clin. Exp. Metastasis 2009; 26(4): 289-298. [ Links ]
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26. Chen X, Li N, LeleYang, Liu J, Chen J, Liu H. Expression of collagen I, collagen III and MMPs-1 on the tension side of distracted tooth using periodontal ligament distraction osteogenesis in beagle dogs. Arch Oral Biol. 2014; 59(11): 1217-1225. [ Links ]
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28. Díaz Caballero A, Méndez Cuadro D, Martínez Serrano E, Orozco Páez J, Velásquez M. Metaloproteinasas de la matriz en Odontología y sus consideraciones desde el campo de la química computacional. Rev Cubana Estomatol [en línea]. 2014: 51(1):80-92 citado: 11 de agosto 2016. Disponible en: http://scielo.sld.cu/pdf/est/v51n1/est09114.pdf [ Links ]
29. Rai B, Kaur J, Jain R, Anand SC. Levels of gingival crevicular metalloproteinases 8 and -9 in periodontitis. Saudi Dent J [en línea] 2010; 22(3): 129-131 citado: 11 de agosto 2016. Disponible en: http://www.saudidentaljournal.com/article/S1013-9052(10)00044-1/pdf
2. Dezerega A, Madrid S, Mundi V, Valenzuela MA, Garrido M, Paredes R, García-Sesnich J, Ortega AV, Gamonal J, Hernández M. Pro-oxidant status and matrix metalloproteinases in apical lesions and gingival crevicular fluid as potential biomarkers for asymptomatic apical periodontitis and endodontic treatment response. J Inflamm (Lond). 2012; 9(1): 8. [ Links ]
3. Kim KA, Chung SB, Hawng EY, Noh SH, Song KH, Kim HH, Kim CH, Park YG. Correlation of expression and activity of matrix metalloproteinase-9 and -2 in human gingival cells of periodontitis patients. J Periodontal Implant Sci. 2013; 43(1): 24-29. [ Links ]
4. Grant M, Wilson J, Rock P, Chapple I. Induction of cytokines, MMPs9, TIMPs, RANKL and OPG during orthodontic tooth movement. Eur J Orthod. 2013; 35(5): 644-651. [ Links ]
5. Cascales M, Álvarez-Gómez JA. Metaloproteinasas, matriz extracelular y cáncer. An R Acad Nac Farm, 2010, 76 (1): 59-84. [ Links ]
6. Coronato S, Laguens G, Vanda Di Girolamo V. Rol de las metaloproteinasas y sus inhibidores en patología tumoral. Medicina (Buenos Aires) [en línea] 2012; 72: 495-502 citado 11 de agosto 2016. Disponible en http://www.scielo.org.ar/pdf/medba/v72n6/v72n6a12.pdf. [ Links ]
7. Kessenbrock K, Plaks V, Werb Z. Matrix Metalloproteinases: Regulators of the Tumor Microenvironment. Cell. 2010; 141(1): 52-67. [ Links ]
10. Schubert-Unkmeir A, Konrad C, Slanina H, Czapek F, Hebling S, Frosch M. Neisseria meningitidis induces brain microvascular endothelial cell detachment from the matrix and cleavage of occludin: a role for MMPs-8. PLoS Pathog [en línea]. 2010; 29; 6(4):e1000874 citado: 11 de agosto 2016. Disponible en: http://dx.doi.org/10.1371/journal.ppat.1000874 [ Links ]
11. Bartlett JD, Smith CE. Modulation of cell-cell Junctional complexes by matrix metalloproteinases. J Dent Res. 2013; 92(1): 10-17. [ Links ]
12. Boushell LW, Nagaoka H, Nagaoka H, Yamauchi M. Increased Matrix Metalloproteinase-2 and Bone Sialoprotein Response to Human Coronal Caries. Caries Res. 2011; 45(5): 453-459. [ Links ]
13. Mazzoni A, Scaffa P, Carrilho M, Tjäderhane L, Di Lenarda R, Polimeni A, Tezvergil-Mutluay A, Tay FR, Pashley DH, Breschi L. Effects of Etch-and-Rinse and Self-etch Adhesives on Dentin MMPs-2 and MMPs-9. J Dent Res. 2013; 92(1): 82-86. [ Links ]
14. Montagner AF, Sarkis-Onofre R, Pereira-Cenci T, Cenci MS. MMPs Inhibitors on Dentin Stability: A Systematic Review and Meta-analysis. J Dent Res. 2014; 93(8): 733-743. [ Links ]
15. Menezes-Silva R, Khaliq S, Deeley K, Letra A, Vieira AR. Genetic Susceptibility to Periapical Disease: Conditional Contribution of MMPs2 and MMPs3 Genes to the Development of Periapical Lesions and Healing Response. J Endod. 2012; 38(5): 604-607. [ Links ]
16. Miao D, Godovikova V, Qian X, Seshadrinathan S, Kapila YL, Fenno JC. Treponema denticola upregulates MMPs-2 activation in periodontal ligament cells: interplay between epigenetics and periodontal infection. Arch Oral Biol. 2014; 59(10): 1056-1064. [ Links ]
17. Zhou J, Zhang J, Chao J. Porphyromonas gingivalis Promotes Monocyte Migration by Activating MMPs-9. J Periodontal Res. 2012; 47(2): 236-242. [ Links ]
18. Gonçalves PF, Huang H, McAninley S, Alfant B, Harrison P, Aukhil I, Walker C, Shaddox LM. Periodontal Treatment Reduces Matrix Metalloproteinase Levels in Localized Aggressive Periodontitis. J Periodontol. 2013; 84(12): 1801-1808. [ Links ]
19. Şurlin P, Oprea B, Solomon SM, Popa SG, Moţa M, Mateescu GO, Rauten AM, Popescu DM, Dragomir LP, Puiu I, Bogdan M, Popescu MR. Matrix metalloproteinase -7, -8, -9 and -13 in gingival tissue of patients with type 1 diabetes and periodontitis. Rom J Morphol Embryol. 2014; 55(3 Suppl): 1137-1141. [ Links ]
20. Arakawa H, Uehara J, Hara ES, Sonoyama W, Kimura A, Kanyama M, Matsuka Y, Kuboki T. Matrix metalloproteinase-8 is the major potential collagenase in active periimplantitis J Prosthodont Res. 2012; 56(4): 249-255. [ Links ]
21. Şurlin P, Rauten AM, Pirici D, Oprea B, Mogoantă L, Camen A. Collagen IV and MMPs-9 expression in hypertrophic gingiva during orthodontic treatment. Rom J Morphol Embryol. 2012; 53(1): 161-165 [ Links ]
22. Wolf K, Friedl P. Mapping proteolytic cancer cell-extracellular matrix interfaces. Clin. Exp. Metastasis 2009; 26(4): 289-298. [ Links ]
23. Paula-Silva FW, da Silva LA, Kapila YL. Matrix metalloproteinase expression in teeth with apical periodontitis is differentially modulated by the modality of root canal treatment. J Endod. 2010; 36(2): 231-237. [ Links ]
24. Zehnder M, Wegehaupt FJ, Attin T. A first study on the usefulness of matrix metalloproteinase 9 from dentinal fluid to indicate pulp inflammation. J Endod. 2011; 37(1): 17-20. [ Links ]
26. Chen X, Li N, LeleYang, Liu J, Chen J, Liu H. Expression of collagen I, collagen III and MMPs-1 on the tension side of distracted tooth using periodontal ligament distraction osteogenesis in beagle dogs. Arch Oral Biol. 2014; 59(11): 1217-1225. [ Links ]
27. Canavarro C, Teles RP, Capelli Júnior J. Matrix metalloproteinases -1, -2, -3, -7, -8, -12, and -13 in gingival crevicular fluid during orthodontic tooth movement: a longitudinal randomized split-mouth study. Eur J Orthod. 2013; 35(5): 652-658. [ Links ]
28. Díaz Caballero A, Méndez Cuadro D, Martínez Serrano E, Orozco Páez J, Velásquez M. Metaloproteinasas de la matriz en Odontología y sus consideraciones desde el campo de la química computacional. Rev Cubana Estomatol [en línea]. 2014: 51(1):80-92 citado: 11 de agosto 2016. Disponible en: http://scielo.sld.cu/pdf/est/v51n1/est09114.pdf [ Links ]
29. Rai B, Kaur J, Jain R, Anand SC. Levels of gingival crevicular metalloproteinases 8 and -9 in periodontitis. Saudi Dent J [en línea] 2010; 22(3): 129-131 citado: 11 de agosto 2016. Disponible en: http://www.saudidentaljournal.com/article/S1013-9052(10)00044-1/pdf