Keywords
non-fibrillary matrix
Regeneration
How to Cite
Abstract
Cementum is a connective tissue with the particularity that its organic matrix is mineralized. Within its components is posible to identify the cementoblasts, the cementocytes and in certain conditions the cementoclasts. In the organic matrix there are two components, one fibrillar, represented mainly by collagen type I, and another non-fibrillar, which includes diverse molecules capable of producing a varied number of functions. Being a mineralized connective, the hydroxyapatite that articulates with the organic matrix to produce this mineralization.The objective of this work is to update the histological-molecular characteristics of cement, and especially the non-fibrillar extracellular matrix components, and how these contribute to maintenance and tissue regeneration
References
Gomez de Ferraris ME, Campos Muñoz A. Periodonto de inserción: cemento, ligamento periodontal y hueso alveolar. En: Histología, Embriología e Ingeniería Tisular Bucodental. Ciudad de México. Panamericana. 4 ed., 2019. p267- 299.
Garant P. Root Formation and Cementogenesis. Oral Cells and Tissues. 1era ed. Canada: Quintessence, 2003. p179-194.
Nancy A. Periodontium. Ten Cate’s Oral Histology. 9 ed. Montreal. Elsevier, 2017. p193-217.
Hakki SS, Foster BL, Nagatomo KJ, Bozkurt SB, Hakki EE, Somerman MJ, Nohutcu RM. Bone morphogenetic protein-7 enhances cementoblast function in vitro. J Periodontol 2010: 81: 1663–1674.
Smith PC, Martínez C, Cáceres M, Martínez J. Research on growth factors in periodontology. Periodontol 2000. 2015; 67: 234-250
Carmagnola D, Pellegrini G, Dellavia C, Rimondini L, Varoni E. Tissue engineering in periodontology: Biological mediators for periodontal regeneration. The International Journal of Artificial Organs.2019; 1-17.
Ripamonti U, Developmental pathways of periodontal tissue regeneration: Developmental diversities of tooth morphogenesis do also map capacity of periodontal tissue regeneration? J Periodontal Res; 54(1): 10-26, 2019 Feb
Yong, J Gröger, S; Von Bremen, J; Ruf, S. Ciliary Neurotrophic Factor (CNTF) Inhibits In Vitro Cementoblast Mineralization and Induces Autophagy, in Part by STAT3/ERK Commitment. Int J Mol Sci; 23(16)2022 Aug 18
Arzate H., Zeichner-Davis M., Mercado-Celis G. Cementum proteins: role in cementogénesis, biomineralization, periodontium formation and regeneration. Periodontol. 2000. 2015; 65: 211-233.
Huang X, Bringas P Jr, Slavkin HC, Chai Y. Fate of HERS during tooth root development, Dev Biol. 2009 Oct 1;334(1):22-30. doi: 10.1016/j.ydbio.2009.06.034. Epub 2009 Jul 1.
Nam H, Kim J, Park J, Park JC, Kim JW, Seo BM, Lee JC, Lee G. Expression profile of the stem cell markers in human Hertwig’s epithelial root sheath/Epithelial rests of Malassez cells. Mol Cells. 2011 Apr;31(4):355-60. doi: 10.1007/s10059-011-0045-3. Epub 2011 Feb 22.
Montoya G, Correa R, Arenas J, Hoz L, Romo E, Arroyo R, Zeichner- Davis M, Arzate H. Cementum protein 1‐derived peptide (CEMP 1‐p1) modulates hydroxyapatite crystal formation in vitro.J Pep Sci. 2019; 1-11.
Kémoun P, Laurencin-Dalicieux S, Rue J, Vaysse F, Roméas A, Arzate H, Conte-Auriol F, Farges JC, Salles. Localization of STRO-1, BMP-2/-3/-7, BMP receptors and phosphorylated Smad-1 during the formation of mouse periodontium. Tissue Cell. 2007 Aug;39(4):257-66. doi: 10.1016/j.
tice.2007.06.001. Epub 2007 Jul 26.
Nuñez J, Vignoletti F, Caffesse R, Sanz M. Cellular therapy in periodontal regeneration. Periodontology 2000. 2019; 79 (1): 107-116
Fu, L; Wang, M; Zhu, G; Zhao, Z; Sun, H; Cao, Z; Xia, H REV-ERBs negatively regulate mineralization of the cementoblasts. Biochem Biophys Res Commun; 587: 9-15, 2022 01 08.
Li, Shengnan; Li, Fan; Zou, Shujuan; Zhang, Li; Bai, Yuxing. PTH1R signalling regulates the mechanotransduction process of cementoblasts under cyclic tensile stress. Eur J Orthod; 40(5): 537-543, 2018 09 28.
Liu, S; Zhou, Y; Chen, Y; Liu, Y; Peng, S; Cao, Z; Xia, H. Bmal1 promotes cementoblast differentiation and cementum mineralization via Wnt/ß-catenin signaling. Acta Histochem; 124(3): 151868, 2022 Apr.
Li, S; Li, F; Zou, S; Zhang, L; Bai, Y. PTH1R signalling regulates the mechanotransduction process of cementoblasts under cyclic tensile stress. Eur J Orthod; 40(5): 537-543, 2018 09 28.
Yang, B; Sun, H; Song, F; Wu, Yu; Wang, J. Yes-associated protein 1 promotes the differentiation and mineralization of cementoblast. J Cell Physiol; 233(3): 2213-2224, 2018 Mar.
Sacramento, CM; Assis, RI; Saito, MT; Coletta, RD; Da Rocha Dourado, M; Sallum, EA; Nociti, FH; Viana Casarin, RC; Andia, DC; Silvério, KG. BMP-2 and asporin expression regulate 5-aza-dC-mediated osteoblast/cementoblast differentiation of periodontal dental ligament mesenchymal progenitor cells. Differentiation; 124: 17-27, 2022.
This work is licensed under a Creative Commons Attribution-NonCommercial 4.0 International License.