Versões
- 2024-07-12 (2)
- 2020-12-06 (1)
Palavras-chave
leucoplasia, carcinoma de células escamosas, acompanhamento, leucoplasia proliferativa.
Como Citar
Protocolo de acompanhamento em leucoplasia proliferativa multifocal para evitar progressão malignos. Apresentação de um caso clínico. (2020). Odontoestomatología, 22(36), 94-102. https://doi.org/10.22592/ode2020n36a11
Resumo
A leucoplasia proliferativa multifocal (LPM) é considerada um dos distúrbios orais potencialmente malignos (DOPM) com a maior taxa de transformação maligna. A terapêutica é extremamente difícil, pois na maioria dos casos as lesões são refratárias. O objetivo deste estudo é relatar um caso de LPM e sua evolução, destacando a importância do monitoramento clínico por meio de protocolos exaustivos de acompanhamento. Uma mulher de 75 anos com múltiplas lesões queratóticas e verrugas por toda a mucosa oral e com um padrão de crescimento proliferativo foi apresentada à consulta. As biópsias e o contexto clínico permitiram ajustá-lo ao diagnóstico de LPM. O paciente aderiu a um protocolo rigoroso e, até o momento, está livre de lesões carcinomatosas. Este trabalho destaca o acompanhamento cuidadoso dos pacientes com esse diagnóstico, a fim alcançar a detecção precoce do carcinoma epidermoide oral e, consequentemente, melhorar o prognóstico.
Referências
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2. Aguirre-Urizar JM. Proliferative multifocal leukoplakia better name that proliferative verrucous leukoplakia. World J Surg Oncol. 2011; 10(9): 122.
3. Hansen LS, Olson JA, Silverman S. Proliferative verrucous leukoplakia. A long-term study of thirty patients. Oral Surg Oral Med Oral Pathol. 1985; 60 (3): 285–98.
4. Cerero-Lapiedra R, Baladé-Martínez D, Moreno- López L-A, Esparza-Gómez G, Bagán JV. Proliferative verrucous leukoplakia: a proposal for diagnostic criteria. Med Oral Patol Oral Cir Bucal. 2010; 15 (6): e839-845.
5. Villa A, Menon RS, Kerr AR, De Abreu Alves F, Guollo A, Ojed D, Woo SB. Proliferative leukoplakia: Proposed new clinical diagnostic criteria. Oral Dis. 2018; 24 (5): 749–60.
6. AK E-N, JKC C, JR G, T T, PJ S. WHO Classification of Head and Neck Tumours [Internet]. [cited 2020 Jan 27]. Available from: https: //publications.iarc.fr/Book-And-Report- Series/Who-Iarc-Classification-Of-Tumours/ Who-Classification-Of-Head-And-Neck-Tumours- 2017
7. Palefsky JM, Silverman S, Abdel-Salaam M, Daniels TE, Greenspan JS. Association between proliferative verrucous leukoplakia and infection with human papillomavirus type 16. J Oral Pathol Med. 1995; 24 (5): 193–7.
8. van der Waal I, Reichart PA. Oral proliferative verrucous leukoplakia revisited. Oral Oncol. 2008; 44 (8): 719–21.
9. Capella DL, Gonçalves JM, Abrantes AAA, Grando LJ, Daniel FI. Proliferative verrucous leukoplakia: diagnosis, management and current advances. Braz J Otorhinolaryngol. 2017; 83 (5): 585–93.
10. Campisi G, Giovannelli L, Ammatuna P, Capra G, Colella G, Di Liberto C, et al. Proliferative verrucous vs conventional leukoplakia: no significantly increased risk of HPV infection. Oral Oncol. 2004; 40 (8): 835–40.
11. Kresty LA, Mallery SR, Knobloch TJ, Li J, Lloyd M, Casto BC, et al. Frequent alterations of p16INK4a and p14ARF in oral proliferative verrucous leukoplakia. Cancer Epidemiol Biomarkers Prev. 2008; 17 (11): 3179–87.
12. Garcia-Pola M-J, Llorente-Pendás S, González- Garcia M, García-Martín J-M. The development of proliferative verrucous leukoplakia in oral lichen planus. A preliminary study. Med Oral Patol Oral Cir Bucal. 2016; 21 (3): e328- 334.
13. Lopes MA, Feio P, Santos-Silva AR, Vargas PA. Proliferative verrucous leukoplakia may initially mimic lichenoid reactions. World J Clin Cases. 2015; 3 (10): 861–3.
14. Thomson PJ, Goodson ML, Smith DR. Potentially malignant disorders revisited-The lichenoid lesion/proliferative verrucous leukoplakia conundrum. J Oral Pathol Med. 2018; 47 (6): 557–65.
15. Fitzpatrick SG, Honda KS, Sattar A, Hirsch SA. Histologic lichenoid features in oral dysplasia and squamous cell carcinoma. Oral Surgery, Oral Medicine, Oral Pathology and Oral Radiology. 2014; 117 (4): 511–20.
16. Cabay RJ, Morton TH, Epstein JB. Proliferative verrucous leukoplakia and its progression to oral carcinoma: a review of the literature. J Oral Pathol Med. 2007; 36 (5): 255–61.
17. Morton T, Cabay R, Epstein J. Proliferative verrucous leukoplakia and its progression to oral carcinoma: Report of three cases. J Oral Path Med. 2007; 36.
18. Munde A, Karle R. Proliferative verrucous leukoplakia: An update. J Cancer Res Ther. 2016; 12 (2): 469–73.
19. Bagan JV, Jimenez Y, Sanchis JM, Poveda R, Milian MA, Murillo J, et al. Proliferative verrucous leukoplakia: high incidence of gingival squamous cell carcinoma. J Oral Pathol Med.
2003; 32 (7): 379–82.
2. Aguirre-Urizar JM. Proliferative multifocal leukoplakia better name that proliferative verrucous leukoplakia. World J Surg Oncol. 2011; 10(9): 122.
3. Hansen LS, Olson JA, Silverman S. Proliferative verrucous leukoplakia. A long-term study of thirty patients. Oral Surg Oral Med Oral Pathol. 1985; 60 (3): 285–98.
4. Cerero-Lapiedra R, Baladé-Martínez D, Moreno- López L-A, Esparza-Gómez G, Bagán JV. Proliferative verrucous leukoplakia: a proposal for diagnostic criteria. Med Oral Patol Oral Cir Bucal. 2010; 15 (6): e839-845.
5. Villa A, Menon RS, Kerr AR, De Abreu Alves F, Guollo A, Ojed D, Woo SB. Proliferative leukoplakia: Proposed new clinical diagnostic criteria. Oral Dis. 2018; 24 (5): 749–60.
6. AK E-N, JKC C, JR G, T T, PJ S. WHO Classification of Head and Neck Tumours [Internet]. [cited 2020 Jan 27]. Available from: https: //publications.iarc.fr/Book-And-Report- Series/Who-Iarc-Classification-Of-Tumours/ Who-Classification-Of-Head-And-Neck-Tumours- 2017
7. Palefsky JM, Silverman S, Abdel-Salaam M, Daniels TE, Greenspan JS. Association between proliferative verrucous leukoplakia and infection with human papillomavirus type 16. J Oral Pathol Med. 1995; 24 (5): 193–7.
8. van der Waal I, Reichart PA. Oral proliferative verrucous leukoplakia revisited. Oral Oncol. 2008; 44 (8): 719–21.
9. Capella DL, Gonçalves JM, Abrantes AAA, Grando LJ, Daniel FI. Proliferative verrucous leukoplakia: diagnosis, management and current advances. Braz J Otorhinolaryngol. 2017; 83 (5): 585–93.
10. Campisi G, Giovannelli L, Ammatuna P, Capra G, Colella G, Di Liberto C, et al. Proliferative verrucous vs conventional leukoplakia: no significantly increased risk of HPV infection. Oral Oncol. 2004; 40 (8): 835–40.
11. Kresty LA, Mallery SR, Knobloch TJ, Li J, Lloyd M, Casto BC, et al. Frequent alterations of p16INK4a and p14ARF in oral proliferative verrucous leukoplakia. Cancer Epidemiol Biomarkers Prev. 2008; 17 (11): 3179–87.
12. Garcia-Pola M-J, Llorente-Pendás S, González- Garcia M, García-Martín J-M. The development of proliferative verrucous leukoplakia in oral lichen planus. A preliminary study. Med Oral Patol Oral Cir Bucal. 2016; 21 (3): e328- 334.
13. Lopes MA, Feio P, Santos-Silva AR, Vargas PA. Proliferative verrucous leukoplakia may initially mimic lichenoid reactions. World J Clin Cases. 2015; 3 (10): 861–3.
14. Thomson PJ, Goodson ML, Smith DR. Potentially malignant disorders revisited-The lichenoid lesion/proliferative verrucous leukoplakia conundrum. J Oral Pathol Med. 2018; 47 (6): 557–65.
15. Fitzpatrick SG, Honda KS, Sattar A, Hirsch SA. Histologic lichenoid features in oral dysplasia and squamous cell carcinoma. Oral Surgery, Oral Medicine, Oral Pathology and Oral Radiology. 2014; 117 (4): 511–20.
16. Cabay RJ, Morton TH, Epstein JB. Proliferative verrucous leukoplakia and its progression to oral carcinoma: a review of the literature. J Oral Pathol Med. 2007; 36 (5): 255–61.
17. Morton T, Cabay R, Epstein J. Proliferative verrucous leukoplakia and its progression to oral carcinoma: Report of three cases. J Oral Path Med. 2007; 36.
18. Munde A, Karle R. Proliferative verrucous leukoplakia: An update. J Cancer Res Ther. 2016; 12 (2): 469–73.
19. Bagan JV, Jimenez Y, Sanchis JM, Poveda R, Milian MA, Murillo J, et al. Proliferative verrucous leukoplakia: high incidence of gingival squamous cell carcinoma. J Oral Pathol Med.
2003; 32 (7): 379–82.