Palabras clave
Ácido Hialurónico, Envejecimiento de la piel, Regeneración.
Cómo citar
Estudio clínico de eficacia, duración y efectos adversos del implante de Ácido Hialurónico en el área Buco-Maxilo-Facial. (2019). Odontoestomatología, 19(30), 77-90. https://odon.edu.uy/ojs/index.php/ode/article/view/166
Resumen
Ensayo Clínico observacional y descriptivo, longitudinal y prospectivo de 22 meses de duración, en 40 pacientes de Facultad Odontología. UDELAR. Objetivo: Valorar efcacia, duración y efectos adversos del implante de Ácido Hialurónico (A.H) realizado en surcos nasolabiales. (SNL) Metodología: Ensayo clínico con implantación de A.H en la dermis media de SNL marcados, grado 2 al 5 en la escala diagnóstica WSRS. Se obtuvieron y clasifcaron registros clínicofotográfcos de cada caso, pre y post-aplicación por 12 meses utilizando las escalas WSRS, GAIS y PSSS. Resultados: expresados en tiempos, porcentajes y gráficos Efcacia: muy buena =100 % casos Duración media clínica efectiva: 10,5 meses Efectos adversos al producto: cero % Califcación de los pacientes: Bueno a muy Bueno. Conclusión: el AH inyectable a nivel dérmico (TEOSYAL Deep Lines®), es eficaz para corregir SNL. Duración promedio 10,5 meses con efecto “caída lento”. Reacciones adversas: cero.
Referencias
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2. Carruthers J, Narurkar VA. Tratamiento de los labios y ángulos de la boca. In: Carruters J. Aumento de Tejidos blandos. Madrid: Elsevier, 2006. pp 109.
3. Rodriguez E et al: Materiales de relleno en el área orofacial. Dentum.2009;9(1):36-41.
4. Lemperle G, Morhenn Vand Charier U. Human histology and persistence off varios injectable fller subtances for soft tissue augmentation. Aesthetice
plast Surg. 2003;27:354
5. Jacovella PJ. Correcciones Faciales Estéticas con Rellenos Inyectables. Buenos Aires: AKADIA, 2008.
6. Bowman PH, Narins RS. Hilanos y aumento de tejidos blandos. In: Carruthers J, Carruthers A, Dover JA, Murad A. Aumento de tejidos blandos. Madrid: Elsevier, 2006. p33.
7. Rzany V, Dil Müller D, Grablowitz D, Heckmann M, Caird D. Repeated Boulinun toxin A injection for the threatments of lines in the upper face: a retrospective study of 4.103 treatments in 945 patients. Dermatol Surg 2007; 33(Sp 1): S18-25
8. Personell J. Anatomía, Fisiología e bioquímica da pele normal e do envelhecimiento cutane. Cosmetria a Ciencia da beleza. Revinter 2004. p3-26
9. Carruthers J, Klein AW, Carruthers A, Glogau RG, Canfeld D. Safety and efcacy of nonamimal stabiliced hyaluronic acid for improvement of the 10. Bezzola A, Micheeles P, Esthelis AC. Hialurónico de diseño Suizo. J Med.Esth Chr Dern. 2005;32:11
11. FriedmanPM et al.Safety data of inyectable noanimal stabilized hyaluronic acid gel for soft tissue aumentation. Derm. Surg. 2002;28:491-4
12. Sanchez C, Candelas D, Ruiz RR. Materiales de relleno: tipo indicaciones y complicaciones. Actas dermosifliogr. 2010;101(5):381-393
13. Necas J, Bartosikova L, Brauner P, Kolar J.. Hyaluronic acid (hyaluronan): a review. 2008. Veterinarni Medicina 53:397-411.
14. Fraser JRE, Laurent TC, Laurent UBG.. Hyaluronan: its nature, distribution, functions and turnover. J Int Med 1997; 242:27-33.
15. Balazs EA et al. Hyaluronan Biomaterials.: Medical applications. In: Wise DL et al. Handbook of Biomaterials and Applications. New York: Marcel Dekker. 1995. p2719-2741.
16. Ogden A, Grifths T.W. A review of minimally invasive cosmetic procedures. Br J Dermatol. 2008; 159:1036-50.
17. Erazo JP, De Carvalho AC et al. Relleno facial con ácido hialurónico: técnica de pilares y malla de sustentación. Principios básicos para obtener una remodelación facial. Cirugía Plástica IberoLatinoam 2009; 35(3).
18. Day D, et al. Te Wrinkle Severity Rating Scale: a validation study. Am.J Clin Dermatol. 2004; 5(1): 49-52
19. Larson L, Rovers J, Mackeigan L. Patient satisfaction with pharmaceutical care: update of a validated instrument. J Am Pharm Assoc 2002;42(1):44-50.
20. Narins R, Brandt F, Leyden J, Lorenc ZP, Rubin M, Smith S. A randomised, double-blind, multicenter comparison of the efcacy and tolerability of Restylane versus Zyplast for the correction of nasolabial folds. Derm. Surg. 2003;29:588-95
21. Baumann LS, Shamban AT, Lupo MP, Monheit GD, Tomas JA, Murphy DK, Walker PS. Comparison of smooth-gel hyaluronic acid dermal fllers with cross-linked bovine: a multicenter, doublé-masket, randomized, within-subject study. Dermatol Surg. 2007;33(Suppl 2):S128-35.
22. Nast A, Reytan N, Harmann V, Pathirana D, Backmann F, Erdmann R, Rzany B. Efcacy and Durability of Two Hyaluronic Acid–Based Fillers in the Correction of Nasolabial Folds: Results of a Prospective, Randomized, Double‐Blind, Actively Controlled Clinical Pilot Study. Dermatology Surg 2011; 37(6): 768-775
23. Grimes PE, Tomas JA, Murphy D.K. Safety and effectiveness of hyaluronic acid fllers in skin of color. J Cosmet Dermatol 2009;8:162-8.
24. Williams S, Tamburic S, Weber M. Changes in skin phisiology and clinical appearance after microdoplet placement of hialuronic acid in aging hands. J Cosmetic Dermatol 2009; 8(3): 216-225.
25. Klein AW. Techniques for soft tissue augmentation: an “A” to “Z”. Am J ClinDermatol 2006;7:107-20.
26. Anido J, Félix S, Jarne C, Milotich A, Moreu C, Ruíz-De-Cueto S, Serna M, Ulecia M, VaqueroPérez MM. Reunión de consenso para recomendaciones sobre la gama de productos Restylane Skinboosters®. Rev. Plastic Iberolatinoam 2016; 42 (2): 187-195. doi: 10.4321/S0376-78922016000200013
27. Kerscher M, Bayrhammer J, Reuther T. Rejuvenating influence of a stabilized hyaluronic acidbased gel of nonanimal origin on facial skin aging. Dermatol Surg. 2008; 34 (5): 720-726.
28. Reuther T, Bayrhammer J, Kerscher M. Effects of a threesession skin rejuvenation treatment using stabilized hyaluronic acid-based gel of non-animal origin on skin elasticity: a pilot study. Arch Dermatol Res 2010; 302 (1): 37-45.
29. Gubanova EI, Dyachenko YY, Rodina MY, Koliyeva MK. New hydrobalance technology based on stabilized hyaluronic acid for long-term skin hydration.
Esteticheskaya Meditsina (Aesthetic Medicine) 2010; 1:94-1098.
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