Palabras clave
parótida; adenocarcinoma de células basales; diagnóstico
Cómo citar
Reporte de caso Adenocarcinoma de celulas basales de glandula parotida: estudio clinico/patologico e inmunohistoquimico. (2018). Odontoestomatología, 20(31), 71-77. https://odon.edu.uy/ojs/index.php/ode/article/view/262
Resumen
El adenocarcinoma de células basales es una neoplasia epitelial con las características citológicas del adenoma de células basales pero con un patrón morfológico de crecimiento infiltrante indicativo de malignidad. Debido a su baja incidencia es a menudo difícil de diagnosticar. El objetivo del presente estudio fue identificar características morfológicas e inmunohistoquímicas que contribuyen a su diagnóstico. Se resecó un tumor de parótida en una paciente de 52 años; se realizó biopsia postoperatoria e inmunomarcación con Ki-67, CK19, p63 y alfa actina de músculo liso. Se diagnosticó adenocarcinoma de células basales mixto sólido y tubular con invasión perineural y de la cápsula tumoral, grasa periglandular y nodos linfoides. La inmunomarcación con Ki-67, CK19, p63 y alfa actina de músculo liso resultó positiva. Posteriormente se diagnosticó una metástasis en seno maxilar. Las características morfológicas, la inmunomarcación Ki-67 positiva y la metástasis le dan el carácter maligno a este tumor, lo que lo diferencia del adenoma de células basales.
Referencias
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6 - Ward BK, Seethala RR, Barnes EL, Lai SY. Basal cell adenocarcinoma of a hard palate minor salivary gland: case report and review of the literature. Head Neck Oncol. 2009; 1: 41. doi: 10.1186/1758-3284-1-41. [ Links ]
7 - Jung MJ, Roh JL, Choi SH, Nam SY, Kim SY, Lee S. Basal cell adenocarcinoma of the salivary gland: a morphological and histochemical comparison with basal cell adenoma with and without capsular invasion. Diag Pathol 2013; 8: 171. doi:10.1186/1746-1596-8-171. [ Links ]
8 - Thotakura M, Tirumalasetti N, Krishna R. Role of Ki-67 labeling index as an adjunct to the histopathological diagnosis and grading of astrocytomas. J Cancer Res Ther 2014; 10: 641-5. [ Links ]
9 - Seethala RR. Basaloid/blue salivary gland tumors. Modern Pathol 2017; 30: S84-S95. [ Links ]
10 - Samar ME, Avila RE, Fonseca I, Ferraris RV, Rabino ZM. Adenoma de células basales de glándulas salivales, variedades sólido y tubular: estudio histopatológico e inmunohistoquímico. Patología Rev Latinoam 2008; 46 (3): 276-83. [ Links ]
11 - Chhieng DC, Paulino AF. Basaloid tumors of the salivary glands. Ann Diag Pathol 2002; 6: 364-72. [ Links ]
12 - Zhan KY, Leutsch EJ. Basal cell adenocarcinoma of the major salivary glands: a population-level study of 509 cases. Laryngoscope 2016; 126 (5): 1089-90. [ Links ]
13 - Chen S, Yang S, Cheu X. Basal cell adenocarcinoma of the buccal minor salivary gland with liver metastasis. An Saudi Med 2015; 35 (4): 318-20. [ Links ]
14 - Sulakshana MS, Deepti SF, Dayananda BS. Basal cell adenocarcinoma of the salivary gland. A rare entity. IAIM 2015; 2/5: 156-9. [ Links ]
15 - Seethala RR; Barnes EL. Rare malignant and benign salivary gland epithelial tumors. Surg Pathol Clin 2011; 4: 1217-72. [ Links ]
16 - Ruiz-Godoy Rivera LA, Luna MA, Luévano Flores E, Mosqueda Taylor A, Barrera Franco JL, Meneses García A. Adenocarcinoma de células basales de glándula salival. Rev. Inst Nal Cancerol (Mex) 1996; 42: 16-21. [ Links ]
17 - Ito FA, Vargas PA, de Almeida OP, Lopes MA. Salivary glands tumors in a brasilian population: a retrospective study of 496 cases. Int J Oral Maxillofac Surg 2005; 34: 533-536. [ Links ]
18 - Wilson TC, Robins RA. Basal cell adenocarcinoma and basal cell adenoma of the salivary glands: A clinicopathological review of seventy tumors with comparison of morphologic features and growth control indices. Head and Neck Pathol 2015; 9: 205-13. [ Links ]
19 - Saluja K, Rao PH, Myers JN, El-Naggar AK. Novel t (1;3) (q21,p21) translocation in a basal cell adenocarcinoma of the parotid gland: potential association with tumorigenesis. Human Pathol 2016; 54: 189-92. [ Links ]
20 - Parashar P, Baron E, Papadimitriou JC, Ord RA, Nikitakis NG. Basal cell adenocarcinoma of the oral minor salivary glands: review of the literature and presentation of two cases. Oral Surg Oral Med Oral Pathol Oral Radiol Endod 2007; 103:77-84. [ Links ]
21 - Hirsch DL, Miles C, Dierks E. Basal cell adenocarcinoma of the parotid gland: report of a case and review of the literature. J Oral Maxillofac Surg 2007; 65: 2385-8 [ Links ]
22 - Jayakrishnan A, Elmalah I, Hussain K, Odell EW. Basal cell adenocarcinoma in minor salivary glands. Histopathology 2003; 42: 610-4. [ Links ]
2 - Ellis GL, Auclair PL. Atlas of tumor pathology: Tumors of the major salivary glands. 4 serie. Fascículo 9. Washington DC. Armed Forces Institute of Pathology (AFIP). 2008. [ Links ]
3 - World Health Organization. International classification of diseases for oncology (ICD-O) - 3º ed. Malta. WHO, 2003. 252p. [ Links ]
4 - Samar ME, Avila RE. Glosario de histopatología: tumores epiteliales de las glándulas salivales. 2º ed. Córdoba. Samar ediciones, 2015. 96p. [ Links ]
5 - Sarafraz Z, Azaraein MH, Moghimi M, Musavi SA. Basal cell adenocarcinoma of the parotid gland in an elderly iranian woman and review of the literature. Otolaryngol (Sunnyvale) 2015; 5: doi: 10.4172/2161-119X.1000180. [ Links ]
6 - Ward BK, Seethala RR, Barnes EL, Lai SY. Basal cell adenocarcinoma of a hard palate minor salivary gland: case report and review of the literature. Head Neck Oncol. 2009; 1: 41. doi: 10.1186/1758-3284-1-41. [ Links ]
7 - Jung MJ, Roh JL, Choi SH, Nam SY, Kim SY, Lee S. Basal cell adenocarcinoma of the salivary gland: a morphological and histochemical comparison with basal cell adenoma with and without capsular invasion. Diag Pathol 2013; 8: 171. doi:10.1186/1746-1596-8-171. [ Links ]
8 - Thotakura M, Tirumalasetti N, Krishna R. Role of Ki-67 labeling index as an adjunct to the histopathological diagnosis and grading of astrocytomas. J Cancer Res Ther 2014; 10: 641-5. [ Links ]
9 - Seethala RR. Basaloid/blue salivary gland tumors. Modern Pathol 2017; 30: S84-S95. [ Links ]
10 - Samar ME, Avila RE, Fonseca I, Ferraris RV, Rabino ZM. Adenoma de células basales de glándulas salivales, variedades sólido y tubular: estudio histopatológico e inmunohistoquímico. Patología Rev Latinoam 2008; 46 (3): 276-83. [ Links ]
11 - Chhieng DC, Paulino AF. Basaloid tumors of the salivary glands. Ann Diag Pathol 2002; 6: 364-72. [ Links ]
12 - Zhan KY, Leutsch EJ. Basal cell adenocarcinoma of the major salivary glands: a population-level study of 509 cases. Laryngoscope 2016; 126 (5): 1089-90. [ Links ]
13 - Chen S, Yang S, Cheu X. Basal cell adenocarcinoma of the buccal minor salivary gland with liver metastasis. An Saudi Med 2015; 35 (4): 318-20. [ Links ]
14 - Sulakshana MS, Deepti SF, Dayananda BS. Basal cell adenocarcinoma of the salivary gland. A rare entity. IAIM 2015; 2/5: 156-9. [ Links ]
15 - Seethala RR; Barnes EL. Rare malignant and benign salivary gland epithelial tumors. Surg Pathol Clin 2011; 4: 1217-72. [ Links ]
16 - Ruiz-Godoy Rivera LA, Luna MA, Luévano Flores E, Mosqueda Taylor A, Barrera Franco JL, Meneses García A. Adenocarcinoma de células basales de glándula salival. Rev. Inst Nal Cancerol (Mex) 1996; 42: 16-21. [ Links ]
17 - Ito FA, Vargas PA, de Almeida OP, Lopes MA. Salivary glands tumors in a brasilian population: a retrospective study of 496 cases. Int J Oral Maxillofac Surg 2005; 34: 533-536. [ Links ]
18 - Wilson TC, Robins RA. Basal cell adenocarcinoma and basal cell adenoma of the salivary glands: A clinicopathological review of seventy tumors with comparison of morphologic features and growth control indices. Head and Neck Pathol 2015; 9: 205-13. [ Links ]
19 - Saluja K, Rao PH, Myers JN, El-Naggar AK. Novel t (1;3) (q21,p21) translocation in a basal cell adenocarcinoma of the parotid gland: potential association with tumorigenesis. Human Pathol 2016; 54: 189-92. [ Links ]
20 - Parashar P, Baron E, Papadimitriou JC, Ord RA, Nikitakis NG. Basal cell adenocarcinoma of the oral minor salivary glands: review of the literature and presentation of two cases. Oral Surg Oral Med Oral Pathol Oral Radiol Endod 2007; 103:77-84. [ Links ]
21 - Hirsch DL, Miles C, Dierks E. Basal cell adenocarcinoma of the parotid gland: report of a case and review of the literature. J Oral Maxillofac Surg 2007; 65: 2385-8 [ Links ]
22 - Jayakrishnan A, Elmalah I, Hussain K, Odell EW. Basal cell adenocarcinoma in minor salivary glands. Histopathology 2003; 42: 610-4. [ Links ]