How to Cite
Bioactive glasses in restorative dentistry. (2019). Odontoestomatología, 21(34), 33-43. https://doi.org/10.22592/ode2019n34a5
Abstract
Bioactive glasses (bg) are ceramic materials
whose chemical composition allows them
to induce and conduct tissue mineralization. As these glasses can be obtained with
the sol-gel method and in nanometric particle sizes, their indication has been extended
and enhanced.
The antibacterial properties of bg are outstanding: they are possible given the release
of ions, which alkalinizes the medium, acting on the bacterial colonies.
The medical and dental applications of
these materials are wide, with an emphasis on bone regeneration, remineralization of hard dental tissues and treatment
of hypersensitivity. However, as they are
materials with an amorphous chemical
structure, their mechanical properties
are not good, this being their main limitation for clinical application in restorative dentistry. In this sense, scientific
research has focused on determining
the possibility of including bg in various dental materials as a way to combine
bioactivity with appropriate mechanical
properties.
So far, it has not been possible to determine the proportion and methodology
necessary to include bg in dental materials without altering their clinical behavior, which is why further research is
necessary.
References
1. Ferracane JL, Cooper PR, Smith AJ. Can interaction of materials with the dentin-pulp
complex contribute to dentin regeneration?
Odontology. 2010; 98 (1): 2-14
2. Krishnan V, Lakshmi T. Bioglass: a novel biocompatible innovation. J adv pharm tech res.
2013; 4 (2): 78-83
3. Salinas AJ, Vallet-Regí M. The sol-gel production of bioceramics. Key engineering materials.
Trans tech publications, 2009; 391:141-158
4. Sarin S, Rekhi A. Bioactive glass: a potential
next generation biomaterial. Srm j res den sci.
2016; 7 (1): 27
5. Saqib A, Imran F, Kefi I. A review of the effect
of various ions on the properties and the clinical applications of novel bioactive glasses in
medicine and dentistry. The saudi dental journal. 2014; 26:1-5.
6. López Piriz R. Vidrios bioactivos en odontología. Gaceta dental. 2016; 281: 104-22
7. Fernando D, Attik N, Pradelle-Plasse N, Jackson P, Grosgogeat B, Colon P. Bioactive glass
for dentin remineralization: a systematic review. Materials science and engineering. 2017.
8. Kaur G, Pandey OP, Singh K, Homa D, Scott
B, Pickrell G. A review of bioactive glasses:
their structure, properties, fabrication and apatite formation. J biomed mater res a. 2014;102
(1): 254-74.
9. Sonarkar S, Purba R. Bioactive materials in
conservative dentistry. Inter j contemp dent
med rev. 2015: 1-4.
10. Sepúlveda Rebaudo G. Evaluación de la bioactividad del cemento biodentine modificado
con nanopartículas de vidrio bioactivo. Universidad de chile, facultad de odontología.
2015.
11. Badami V, Ahuja B. Biosmart materials: breaking new ground in dentistry. Scientific world j. 2014; 2014:
986912. Doi:10.1155/2014/986912
12. Abbasi Z, Bahrololoum ME, Bagheri R, Shariat MH. Characterization of the bioactive and
mechanical behavior of dental ceramic/sol-gel
derived bioactive glass mixtures. J of the mechanical behavior of biomedical materials.
2016; 54: 115-22.
13. Polini A, Bai H, Tomsia A. Dental applications
of nanostructured bioactive glass and its composites. Wiley interdiscip rev nanomed nanobiotechnol. 2014; 5 (4): 399–410
14. Hench L. The story of bioglass. J mater sci:
mater med.2006; 17: 967–978 .
15. Khoroushi M, Keshani F. A review of glassionomers: from conventional glass-ionomer to
bioactive glass-ionomer. Dental research journal. 2013; 10 (4): 411-420.
16. Narayana S, Deepa VK, Ahamed S, Sathish
ES, Meyappan R, Kumar S. Remineralization
efficiency of bioactive glass on artificially induced carious lesion an in-vitro study. Journal of
indian society of pedodontics and preventive
dentistry. 2014; 32(1): 19-25.
17. Hench, LL. Bioceramics: from concept to clinic. J american cer soc. 1991; 74 (7): 1487-1510.
18. Salonen JI, Arjasamaa M, Tuominen U, Behbehani MJ, Zaatar EI. Bioactive glass in dentistry. J minim interv dent. 2009; 2 (4): 208-18.
19. Jones JR. Review of bioactive glass: from
hench to hybrids. Acta biomaterialia. 2013; 9
(1): 4457-4486.
20. Aguiar H, Serra J, González P. Los vidrios bioactivos en el mundo de los biomateriales. An.
Quím. 2011; 107 (3): 237–42.
42
María Inés Garchitorena
21. Hench L. Chronology of bioactive glass development and clinical applications. New journal of glass and ceramics. 2013; 3 (2): 67-73.
22. Sepulveda P, Jones JR, Hench LL. Characterization of melt-derived 45s5 and sol-gelderived 58s bioactive glasses. J biomed mater
res. 2001; 58 (6): 734-40.
23. Abbasi Z, Bahrololoom ME, Shariat MH,
Bagheri R. Bioactive glasses in dentistry: a review. J dent biomater. 2015; 2 (1):1-9.
24. Allan I, Newman H, Wilson M. Antibacterial
activity of particulate bioglass against supra
and subgingival bacteria .Biomaterials. 2001;
22: 1683-87.
25. Stanciu GA, Stanciu SG, Sandulescu I, Bogdan Savu. Investigation of the hydroxyapatite
growth on bioactive glass surface. J. Biomed.
Pharm. Eng. 2007; (1): 34-9.
26. Goudouri OM, Kontonasaki E, Papadopoulou
L, Manda M, Kavouras P, Triantafyllidis KS.,
Paraskevopoulos KM. An experimental bioactive dental ceramic for metal-ceramic restorations: textural characteristics and investigation
of the mechanical properties. J mec behavior
biomed mater. 2017; 66: 95-103.
27. Matsuya S, Matsuya Y, Ohta M. Structure
of bioactive glass and its application to glass
ionomer cement. Dent mater j. 1999;18 (2):
155-66
28. Khvostenko D, Hilton TJ, Ferracane JL, Mitchell JC, Kruzic JJ. Bioactive glass fillers reduce bacterial penetration into marginal gaps for
composite restorations. Dent mater. 2015; 32
(1): 73-81.
29. Brauer DS, Karpukhina N, O’donnell
MD, Law RV, Hill RG. Fluoride-containing
bioactive glasses: effect of glass design and
structure on degradation, ph and apatite formation in simulated body fluid. Acta biomater. 2010; 6 (8): 3275-82.
30. Efflandt SE, Magne P, Douglas WH, Francis
Lf. Interaction between bioactive glasses and
human dentin. Journal of materials science:
materials in medicine. 2002; 13 (6): 557-65.
31. Forsback AP, Areva S, Salonen J. Mineralization of dentin induced by treatment with bioactive glass s53p4 in vitro. Acta odontologica
scandinavica. 2004; 62 (1): 14-20.
32. Hannig M, Hannig C. Nanomaterials in preventive dentistry. Nat nanotechnol. 2010; 5:
565–9.
33. Vollenweider M, Brunner TJ, Knecht S, Grass
Rn, Zehnder M, Imfeld T, Stark Wj. Remineralization of human dentin using ultrafine
bioactive glass particles. Acta biomater. 2007;
3: 936-43.
34. Khoroushi M, Mousavinasab SM, Keshani F,
Hashemi S. Effect of resin-modified glass ionomer containing bioactive glass on the flexural strength and morphology of demineralized
dentin. Oper dent. 2013; 38 (2): E21-e30.
35. Sauro S, Osorio R, Watson Tf, Toledano
M. Therapeutic effects of novel resin bonding systems containing bioactive glasses on
mineral-depleted areas within thebonded-
dentineinterface.J mater sci mater med .2012;
23: 1521–32
36. Crovace M C, Souza M T, Chinaglia C R, Peitl
O, Zanotto E D. Biosilicate®—a multipurpose, highly bioactive glass-ceramic. In vitro, in
vivo and clinical trials. J of non-crystalline solids. 2016; 432: 90-110
37. Kumar A, Singh S, Thumar G, Mengji A. Bioactive glass nanoparticles (novamin®) for applications in dentistry. J dent and med. 2015;14
(8):30-5
38. Banerjee A, Hajatdoost-Sani M, Farrell S,
Thompson I. A clinical evaluation and comparison of bioactive glass and sodium bicarbonate air-polishing powders. J dent. 2010; 38
(6): 475-79.
39. Farooq I, Imran Z, Farooq U, Leghari A, Ali
H. Bioactive glass: a material for the future.
World j dent. 2012; 3 (2):199-201.
40. Davis HB, Gwinner F, Mitchell JC, Ferracane
JL. Ion release from, and fluoride recharge of a
composite with a fluoride-containing bioactive
glass. Dent mater. 2014; 30 (10): 1187-1194.
41. Ana ID, Matsuya S, Ohta M, Ishikawa K.
Effects of added bioactive glass on the setting
and mechanical properties of resin-modified
glass ionomer cement. Biomaterials. 2003; 24
(18): 3061-67.
42. Yli-Urpo H, Narhi M, Narhi T. Compuond
changes and tooth mineralization effects of
a glass ionomer cements containing bioacti-
43
Vidrios bioactivos en odontología restauradora
María Inés Garchitorena: migarchitorena@gmail.com
ve glass (s53p4), an in vivo study. Biomater.
2005; 26: 5934-41.
43. Choi JY, Lee HH, Kim HW. Bioactive sol-gel
glass added ionomer cement for the regeneration of tooth structure. Journal of materials
science: materials in medicine. 2008; 19 (10):
3287-94.
44. Khvostenko D, Mitchell JC, Hilton TJ, Ferracane JL, Kruzic JJ. Mechanical performance of
novel bioactive glass containing dental restorative composites. Dent mater. 2013; 29 (11):
1139-1148.
45. Bauer J, Carvalho EM, Carvalho CN, Meier
MM, de Souza JP, De Carvalho RM, Loguercio AD. Development of a simplified etchand-rinse adhesive containing niobiophosphate bioactive glass. International journal of
adhesion and adhesives. 2016; 69: 110-14.
46. Goudouri OM, Kontonasaki E, Theocharidou A, Kantiranis N, Chatzistavrou
X, Koidis P, Paraskevopoulos KM. Dental
ceramics/bioactive glass composites: characterization and mechanical properties investigation. Bioceramics development and
applications. 2011; 1:1-4.
47. Manda M, Goudouri OM, Papadopoulou L,
Kantiranis N, Christofilos D, Triantafyllidis
K, Koidis P. Material characterization and
bioactivity evaluation of dental porcelain modified by bioactive glass. Ceramics international.2012; 38 (7): 5585-5596.
complex contribute to dentin regeneration?
Odontology. 2010; 98 (1): 2-14
2. Krishnan V, Lakshmi T. Bioglass: a novel biocompatible innovation. J adv pharm tech res.
2013; 4 (2): 78-83
3. Salinas AJ, Vallet-Regí M. The sol-gel production of bioceramics. Key engineering materials.
Trans tech publications, 2009; 391:141-158
4. Sarin S, Rekhi A. Bioactive glass: a potential
next generation biomaterial. Srm j res den sci.
2016; 7 (1): 27
5. Saqib A, Imran F, Kefi I. A review of the effect
of various ions on the properties and the clinical applications of novel bioactive glasses in
medicine and dentistry. The saudi dental journal. 2014; 26:1-5.
6. López Piriz R. Vidrios bioactivos en odontología. Gaceta dental. 2016; 281: 104-22
7. Fernando D, Attik N, Pradelle-Plasse N, Jackson P, Grosgogeat B, Colon P. Bioactive glass
for dentin remineralization: a systematic review. Materials science and engineering. 2017.
8. Kaur G, Pandey OP, Singh K, Homa D, Scott
B, Pickrell G. A review of bioactive glasses:
their structure, properties, fabrication and apatite formation. J biomed mater res a. 2014;102
(1): 254-74.
9. Sonarkar S, Purba R. Bioactive materials in
conservative dentistry. Inter j contemp dent
med rev. 2015: 1-4.
10. Sepúlveda Rebaudo G. Evaluación de la bioactividad del cemento biodentine modificado
con nanopartículas de vidrio bioactivo. Universidad de chile, facultad de odontología.
2015.
11. Badami V, Ahuja B. Biosmart materials: breaking new ground in dentistry. Scientific world j. 2014; 2014:
986912. Doi:10.1155/2014/986912
12. Abbasi Z, Bahrololoum ME, Bagheri R, Shariat MH. Characterization of the bioactive and
mechanical behavior of dental ceramic/sol-gel
derived bioactive glass mixtures. J of the mechanical behavior of biomedical materials.
2016; 54: 115-22.
13. Polini A, Bai H, Tomsia A. Dental applications
of nanostructured bioactive glass and its composites. Wiley interdiscip rev nanomed nanobiotechnol. 2014; 5 (4): 399–410
14. Hench L. The story of bioglass. J mater sci:
mater med.2006; 17: 967–978 .
15. Khoroushi M, Keshani F. A review of glassionomers: from conventional glass-ionomer to
bioactive glass-ionomer. Dental research journal. 2013; 10 (4): 411-420.
16. Narayana S, Deepa VK, Ahamed S, Sathish
ES, Meyappan R, Kumar S. Remineralization
efficiency of bioactive glass on artificially induced carious lesion an in-vitro study. Journal of
indian society of pedodontics and preventive
dentistry. 2014; 32(1): 19-25.
17. Hench, LL. Bioceramics: from concept to clinic. J american cer soc. 1991; 74 (7): 1487-1510.
18. Salonen JI, Arjasamaa M, Tuominen U, Behbehani MJ, Zaatar EI. Bioactive glass in dentistry. J minim interv dent. 2009; 2 (4): 208-18.
19. Jones JR. Review of bioactive glass: from
hench to hybrids. Acta biomaterialia. 2013; 9
(1): 4457-4486.
20. Aguiar H, Serra J, González P. Los vidrios bioactivos en el mundo de los biomateriales. An.
Quím. 2011; 107 (3): 237–42.
42
María Inés Garchitorena
21. Hench L. Chronology of bioactive glass development and clinical applications. New journal of glass and ceramics. 2013; 3 (2): 67-73.
22. Sepulveda P, Jones JR, Hench LL. Characterization of melt-derived 45s5 and sol-gelderived 58s bioactive glasses. J biomed mater
res. 2001; 58 (6): 734-40.
23. Abbasi Z, Bahrololoom ME, Shariat MH,
Bagheri R. Bioactive glasses in dentistry: a review. J dent biomater. 2015; 2 (1):1-9.
24. Allan I, Newman H, Wilson M. Antibacterial
activity of particulate bioglass against supra
and subgingival bacteria .Biomaterials. 2001;
22: 1683-87.
25. Stanciu GA, Stanciu SG, Sandulescu I, Bogdan Savu. Investigation of the hydroxyapatite
growth on bioactive glass surface. J. Biomed.
Pharm. Eng. 2007; (1): 34-9.
26. Goudouri OM, Kontonasaki E, Papadopoulou
L, Manda M, Kavouras P, Triantafyllidis KS.,
Paraskevopoulos KM. An experimental bioactive dental ceramic for metal-ceramic restorations: textural characteristics and investigation
of the mechanical properties. J mec behavior
biomed mater. 2017; 66: 95-103.
27. Matsuya S, Matsuya Y, Ohta M. Structure
of bioactive glass and its application to glass
ionomer cement. Dent mater j. 1999;18 (2):
155-66
28. Khvostenko D, Hilton TJ, Ferracane JL, Mitchell JC, Kruzic JJ. Bioactive glass fillers reduce bacterial penetration into marginal gaps for
composite restorations. Dent mater. 2015; 32
(1): 73-81.
29. Brauer DS, Karpukhina N, O’donnell
MD, Law RV, Hill RG. Fluoride-containing
bioactive glasses: effect of glass design and
structure on degradation, ph and apatite formation in simulated body fluid. Acta biomater. 2010; 6 (8): 3275-82.
30. Efflandt SE, Magne P, Douglas WH, Francis
Lf. Interaction between bioactive glasses and
human dentin. Journal of materials science:
materials in medicine. 2002; 13 (6): 557-65.
31. Forsback AP, Areva S, Salonen J. Mineralization of dentin induced by treatment with bioactive glass s53p4 in vitro. Acta odontologica
scandinavica. 2004; 62 (1): 14-20.
32. Hannig M, Hannig C. Nanomaterials in preventive dentistry. Nat nanotechnol. 2010; 5:
565–9.
33. Vollenweider M, Brunner TJ, Knecht S, Grass
Rn, Zehnder M, Imfeld T, Stark Wj. Remineralization of human dentin using ultrafine
bioactive glass particles. Acta biomater. 2007;
3: 936-43.
34. Khoroushi M, Mousavinasab SM, Keshani F,
Hashemi S. Effect of resin-modified glass ionomer containing bioactive glass on the flexural strength and morphology of demineralized
dentin. Oper dent. 2013; 38 (2): E21-e30.
35. Sauro S, Osorio R, Watson Tf, Toledano
M. Therapeutic effects of novel resin bonding systems containing bioactive glasses on
mineral-depleted areas within thebonded-
dentineinterface.J mater sci mater med .2012;
23: 1521–32
36. Crovace M C, Souza M T, Chinaglia C R, Peitl
O, Zanotto E D. Biosilicate®—a multipurpose, highly bioactive glass-ceramic. In vitro, in
vivo and clinical trials. J of non-crystalline solids. 2016; 432: 90-110
37. Kumar A, Singh S, Thumar G, Mengji A. Bioactive glass nanoparticles (novamin®) for applications in dentistry. J dent and med. 2015;14
(8):30-5
38. Banerjee A, Hajatdoost-Sani M, Farrell S,
Thompson I. A clinical evaluation and comparison of bioactive glass and sodium bicarbonate air-polishing powders. J dent. 2010; 38
(6): 475-79.
39. Farooq I, Imran Z, Farooq U, Leghari A, Ali
H. Bioactive glass: a material for the future.
World j dent. 2012; 3 (2):199-201.
40. Davis HB, Gwinner F, Mitchell JC, Ferracane
JL. Ion release from, and fluoride recharge of a
composite with a fluoride-containing bioactive
glass. Dent mater. 2014; 30 (10): 1187-1194.
41. Ana ID, Matsuya S, Ohta M, Ishikawa K.
Effects of added bioactive glass on the setting
and mechanical properties of resin-modified
glass ionomer cement. Biomaterials. 2003; 24
(18): 3061-67.
42. Yli-Urpo H, Narhi M, Narhi T. Compuond
changes and tooth mineralization effects of
a glass ionomer cements containing bioacti-
43
Vidrios bioactivos en odontología restauradora
María Inés Garchitorena: migarchitorena@gmail.com
ve glass (s53p4), an in vivo study. Biomater.
2005; 26: 5934-41.
43. Choi JY, Lee HH, Kim HW. Bioactive sol-gel
glass added ionomer cement for the regeneration of tooth structure. Journal of materials
science: materials in medicine. 2008; 19 (10):
3287-94.
44. Khvostenko D, Mitchell JC, Hilton TJ, Ferracane JL, Kruzic JJ. Mechanical performance of
novel bioactive glass containing dental restorative composites. Dent mater. 2013; 29 (11):
1139-1148.
45. Bauer J, Carvalho EM, Carvalho CN, Meier
MM, de Souza JP, De Carvalho RM, Loguercio AD. Development of a simplified etchand-rinse adhesive containing niobiophosphate bioactive glass. International journal of
adhesion and adhesives. 2016; 69: 110-14.
46. Goudouri OM, Kontonasaki E, Theocharidou A, Kantiranis N, Chatzistavrou
X, Koidis P, Paraskevopoulos KM. Dental
ceramics/bioactive glass composites: characterization and mechanical properties investigation. Bioceramics development and
applications. 2011; 1:1-4.
47. Manda M, Goudouri OM, Papadopoulou L,
Kantiranis N, Christofilos D, Triantafyllidis
K, Koidis P. Material characterization and
bioactivity evaluation of dental porcelain modified by bioactive glass. Ceramics international.2012; 38 (7): 5585-5596.