Abstract
Oral cavity cancer and head and neck region occurs most often between the fifth and sixth decade of life and is generally attributed to the indiscriminate use of substances such as alcohol and snuff for a period of time. However, recent studies show an increased incidence in younger patients who have never been exposed to these and other risk factors such as occupational factors, genetic predisposition, diet. Four cases of oral carcinoma are presented as well as a literature review
Palabras clave : oral cancer; squamous cell carcinoma; young patients.
References
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3. Tremblay S, Pintor Dos Reis P, Bradley G, Galloni NN, Perez-Ordonez B, Freeman J, Brown D, Gilbert R, Gullane P, Irish J, Kamel-Reid S. Young Patients with Oral Squamous cell carcinoma. Arch Otolaryngol Head Neck Surg. 2006; 132:958-966. [ Links ]
4. Cervigne NK, Machado J, Gowswami RS, Sadikovic B, Bradley G, Perez-Ordonez B et al. Recurrent genomic alterations in sequential progressive leukoplakia and oral cancer: drivers of oral tumorigenesis? Hum Mol Genet. 2014; 23(10):2618-28. [ Links ]
7. Merletti F, Boffetta P, Ferro G, Pisani P, Terracini B. Occupation and cancer of the oral cavity and oropharynx in Turin, Italy. Scand J Work Environ Health 1991; 17:248-54. [ Links ]
8. Becher H, Flesch-Janys D, Kauppinen T, Kogevinas M, Steindorf K, Manz A, Wahrendorf J. Cancer mortality in German male workers exposed to phenoxy herbicides and dioxins Cancer Causes Control. 1996 May; 7(3):312-21. [ Links ]
10. Thumfart W, Weidenbercher M, Waller G, Pesch HG. Chronic mechanical trauma in the aetiology of oro-pharyngeal carcinoma. J Maxillofac Surg 1978 Aug; 6(3): 217-21. [ Links ]
13. Reing JE, Gollin SM, Saunders WS. The occurrence of chromosome segregation defects is an intrinsic and heritable property of oral squamous cell carcinoma cell lines. Cancer Genet Cytogenet 2004; 150(1):57-61. [ Links ]