Resumo
El cáncer en cavidad bucal y de la región de cabeza y cuello se presenta con mayor frecuencia entre la quinta y sexta década de la vida generalmente atribuido al uso indiscriminado de substancias como el alcohol y el tabaco por un periodo de tiempo considerable. Sin embargo estudios recientes demuestran un incremento en la incidencia en pacientes jóvenes que nunca estuvieron expuestos a estos y a otros factores como riesgo ocupacional, predisposición genética, dieta. Se presenta 4 casos de carcinomas en cavidad bucal y revisión de la literatura
Palabras clave : cáncer bucal; carcinoma de células escamosas; pacientes jóvenes.
Referências
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3. Tremblay S, Pintor Dos Reis P, Bradley G, Galloni NN, Perez-Ordonez B, Freeman J, Brown D, Gilbert R, Gullane P, Irish J, Kamel-Reid S. Young Patients with Oral Squamous cell carcinoma. Arch Otolaryngol Head Neck Surg. 2006; 132:958-966. [ Links ]
4. Cervigne NK, Machado J, Gowswami RS, Sadikovic B, Bradley G, Perez-Ordonez B et al. Recurrent genomic alterations in sequential progressive leukoplakia and oral cancer: drivers of oral tumorigenesis? Hum Mol Genet. 2014; 23(10):2618-28. [ Links ]
7. Merletti F, Boffetta P, Ferro G, Pisani P, Terracini B. Occupation and cancer of the oral cavity and oropharynx in Turin, Italy. Scand J Work Environ Health 1991; 17:248-54. [ Links ]
8. Becher H, Flesch-Janys D, Kauppinen T, Kogevinas M, Steindorf K, Manz A, Wahrendorf J. Cancer mortality in German male workers exposed to phenoxy herbicides and dioxins Cancer Causes Control. 1996 May; 7(3):312-21. [ Links ]
10. Thumfart W, Weidenbercher M, Waller G, Pesch HG. Chronic mechanical trauma in the aetiology of oro-pharyngeal carcinoma. J Maxillofac Surg 1978 Aug; 6(3): 217-21. [ Links ]
13. Reing JE, Gollin SM, Saunders WS. The occurrence of chromosome segregation defects is an intrinsic and heritable property of oral squamous cell carcinoma cell lines. Cancer Genet Cytogenet 2004; 150(1):57-61. [ Links ]