Keywords
periapical lesions
diabetes mellitus
How to Cite
Abstract
Periapical lesions are inflammatory processes that generate the resorption of mineralized tissues. In diabetic patients this process
may be affected. This work aims to identify the association between diabetes mellitus and periapical lesions and to know if diabetic patients have a higher prevalence and severity. A comprehensive review of the available literature, of a narrative type, was carried out. The PubMed (Medline) and SciELO databases and the Timbó and Google Scholar resources were consulted. The exclusion criteria were: works prior to the year 2010 and case reports. Articles prior to the exclusion date were included, as they were considered relevant to the work. Despite the fact that the scientific evidence is still insufficient and the design of the studies should be improved, an association between periapical lesions and diabetes mellitus has been demonstrated. This implies that diabetic patients could have a higher prevalence and severity of lesions.
References
Holland R, Gomes Filho JE, Cintra LTA, Queiroz IODA, Estrela C. Factors affecting the periapical healing process of endodontically treated teeth. J Appl Oral Sci. 2017;25(5):465–76.
MINISTERIO DE SALUD PUBLICA DE URUGUAY M. 2a Encuesta Nacional de Factores de Riesgo de Enfermedades No Transmisibles. 2013;83. Available from: http://www.who.int/chp/steps/2DA_ENCUESTA_NACIONAL_final_WEB22.pdf?ua=1
Lorenzo-Erro SM, Skapino E, Musto M, Olmos P, Álvarez R, Fabruccini A, et al. Salud Bucal y Enfermedades no transmisibles en pacientes de un centro de enseñanza universitaria, Montevideo-Uruguay. Parte 1. Odontoestomatologia. 2020;22(36):55–64.
Lima SMF, Grisi DC, Kogawa EM, Franco OL, Peixoto VC, Gonçalves-Júnior JF, et al. Diabetes mellitus and inflammatory pulpal and periapical disease: A review. Int Endod J. 2013;46(8):700–9.
Tjäderhane L. Endodontic infections and systemic health - where should we go? Int Endod J. 2015;48(10):911–2.
Genco RJ, Borgnakke WS. Diabetes as a potential risk for periodontitis: association studies. Periodontol 2000. 2020;83(1):40–5.
Sanz M, Ceriello A, Buysschaert M, Chapple I, Demmer RT, Graziani F, et al. Scientific evidence on the links between periodontal diseases and diabetes: Consensus report and guidelines of the joint workshop on periodontal diseases and diabetes by the International Diabetes Federation and the European Federation of Periodontology. J Clin Periodontol. 2018;45(2):138–49.
Segura-Egea JJ, Martín-González J, Castellanos-Cosano L. Endodontic medicine: Connections between apical periodontitis and systemic diseases. Int Endod J. 2015;48(10):933–51.
López-López J, Jané-Salas E, Estrugo-Devesa A, Velasco-Ortega E, Martín-González J, Segura-Egea JJ. Periapical and endodontic status of type 2 diabetic patients in Catalonia, Spain: A cross-sectional study. J Endod. 2011;37(5):598–601.
Cintra LTA, Estrela C, Azuma MM, Queiroz índia O de A, Kawai T, Gomes-Filho JE. Endodontic medicine: Interrelationships among apical periodontitis, systemic disorders, and tissue responses of dental materials. Braz Oral Res. 2018;32:66–81.
Al-Zahrani MS, Abozor BM, Zawawi KH. The relationship between periapical lesions and the serum levels of glycosylated hemoglobin and C-reactive protein in type 2 diabetic patients. Saudi Med J. 2017;38(1):36–40.
Wolle CFB, Zollmann LA, Bairros PO, Etges A, Leite CE, Morrone FB, et al. Outcome of periapical lesions in a rat model of type 2 diabetes: Refractoriness to systemic antioxidant therapy. J Endod. 2013;39(5):643–7.
Armada-Dias L, Breda J, Provenzano JC, Breitenbach M, Rôças IDN, Gahyva SMM, et al. Development of periradicular lesions in normal and diabetic rats. J Appl Oral Sci. 2006;14(5):371–5.
Arya S, Duhan J, Tewari S, Sangwan P, Ghalaut V, Aggarwal S. Healing of Apical Periodontitis after Nonsurgical Treatment in Patients with Type 2 Diabetes. J Endod [Internet]. 2017;43(10):1623–7. Available from: http://dx.doi.org/10.1016/j.joen.2017.05.013
Correia-Sousa J, Madureira AR, Carvalho MF, Teles AM, Pina-Vaz I. Apical periodontitis and related risk factors: Cross-sectional study. Rev Port Estomatol Med Dent e Cir Maxilofac [Internet]. 2015;56(4):226–32. Available from: http://dx.doi.org/10.1016/j.rpemd.2015.08.004
Marques Ferreira M, Carrilho E, Carrilho F. Diabetes Mellitus e sua infuência no sucesso do tratamento endodôntico: Um estudo clínico retrospetivo. Acta Med Port. 2014;27(1):15–22.
Fouad, A. F. BJ. The effect of diabetes mellitus on endodontic treatment outcome Data from an electronic patient record. JADA. 2003;134(january):43–51.
Limeira FIR, Arantes DC, de Souza Oliveira C, de Melo DP, Magalhães CS, Bento PM. Root Canal Treatment and Apical Periodontitis in a Brazilian Population with Type 1 Diabetes Mellitus: A Crosssectional Paired Study. J Endod. 2020;46(6):756–62.
Marotta PS, Fontes T V., Armada L, Lima KC, Rôças IN, Siqueira JF. Type 2 diabetes mellitus and the prevalence of apical periodontitis and endodontic treatment in an adult brazilian population. J Endod. 2012;38(3):297–300.
Sánchez-Domínguez B, López-López J, Jané-Salas E, Castellanos-Cosano L, Velasco-Ortega E, SeguraEgea JJ. Glycated Hemoglobin Levels and Prevalence of Apical Periodontitis in Type 2 Diabetic Patients. J Endod. 2015;41(5):601–6.
Ørstavik D, Kerekes K, Eriksen HM. The periapical index: A scoring system for radiographic assessment of apical periodontitis. Dent Traumatol. 1986;2(1):20–34.
Cintra LTA, Samuel RO, Facundo ACS, Prieto AKC, Sumida DH, Bomfim SRM, et al. Relationships between oral infections and blood glucose concentrations or HbA1c levels in normal and diabetic rats. Int Endod J. 2014;47(3):228–37.
De la Torre-Luna R, Domínguez-Pérez RA, Guillén-Nepita AL, Ayala-Herrera JL, Martínez-Martínez RE, Romero-Ayala ME, et al. Prevalence of Candida albicans in primary endodontic infections associated with a higher frequency of apical periodontitis in type two diabetes mellitus patients. Eur J Clin Microbiol Infect Dis. 2020;39(1):131–8.
Sasaki H, Hirai K, M. Martins C, Furusho H, Battaglino R, Hashimoto K. Interrelationship Between Periapical Lesion and Systemic Metabolic Disorders. Curr Pharm Des. 2016;22(15):2204–15.
Quezada García MA, Palma Eyzaguirre AM. Relación bidireccional entre diabetes mellitus y periodontitis apical. ARS MEDICA Rev Ciencias Médicas. 2018;43(3):67–76.
Gomes CC, Guimarães LS, Pinto LCC, Camargo GADCG, Valente MIB, Sarquis MIDM. Investigations of the prevalence and virulence of candida albicans in periodontal and endodontic lesions in diabetic and normoglycemic patients. J Appl Oral Sci. 2017;25(3):274–81.
Iwama A, Nishigaki N, Nakamura K, Imaizumi I, Shibata N, Yamasaki M, et al. The effect of high sugar intake on the development of periradicular lesions in rats with type 2 diabetes. J Dent Res. 2003;82(4):322–5.
Kodama Y, Matsuura M, Sano T, Nakahara Y, Ozaki K, Narama I, et al. Diabetes enhances dental caries and apical periodontitis in caries-susceptible WBN/KobSlc rats. Comp Med. 2011;61(1):53–9.
Samuel RO, Ervolino E, de Azevedo Queiroz ÍO, Azuma MM, Ferreira GT, Cintra LTA. Th1/Th2/Th17/Treg Balance in Apical Periodontitis of Normoglycemic and Diabetic Rats. J Endod. 2019;45(8):1009–15.
Sano T, Matsuura T, Ozaki K, Narama I. Dental caries and Caries-Related periodontitis in type 2 diabetic mice. Vet Pathol. 2011;48(2):506–12.
Sisli SN. Evaluation of the Relationship between Type II Diabetes Mellitus and the Prevalence of Apical Periodontitis in Root-Filled Teeth Using Cone Beam Computed Tomography: An Observational Cross-Sectional Study. Med Princ Pract. 2019;28(6):533–8.
Pérez-Losada F, López-López J, Martín-González J, Jané-Salas E, Segura-Egea JJ, Estrugo-Devesa A. Apical periodontitis and glycemic control in type 2 diabetic patients: Cross-sectional study. J Clin Exp Dent. 2020;12(10):e964–71.
Smadi L. Apical periodontitis and endodontic treatment in patients with type II diabetes mellitus: Comparative cross-sectional survey. J Contemp Dent Pract. 2017;18(5):358–62.
Mesgarani A, Eshkevari N, Ehsani M, Khafri S, Nafarzade S, Damankesh Z. Frequency of odontogenic periradicular lesions in diabetic patients. Casp J Intern Med. 2014;5(1):22–5.
Segura-Egea JJ, Jiménez-Pinzón A, Ríos-Santos J V., Velasco-Ortega E, Cisneros-Cabello R, PoyatoFerrera M. High prevalence of apical periodontitis amongst type 2 diabetic patients. Int Endod J. 2005;38(8):564–9.
Pérez-Losada F de L, Estrugo-Devesa A, Castellanos-Cosano L, Segura-Egea JJ, López-López J, Velasco-Ortega E. Apical Periodontitis and Diabetes Mellitus Type 2: A Systematic Review and MetaAnalysis. J Clin Med. 2020;9(2):540.
Riós-Osorio N, Munõz-Alvear HD, Canõ´n SM, Restrepo-Mendez S, Aguilera-Rojas SE, Jiménez-Penã O, et al. Association between type 2 diabetes mellitus and the evolution of endodontic pathology. Quintessence Int (Berl). 2020;51(2):100–7.
Budreikaitė K, Varoneckaitė M, Oleinikaitė D, Žilinskas J. Association between apical periodontitis and root canal treatment in patients with type II diabetes. A systematic review. Stomatologija. 2022;24(4):100–3.
Fouad AF. Diabetes Mellitus as a Modulating Factor of Endodontic Infections. J Dent Educ. 2003;67(4):459–67.
Segura-Egea JJ, Castellanos-Cosano L, Machuca G, López-López J, Martín-González J, Velasco-Ortega E, et al. Diabetes mellitus, periapical inflammation and endodontic treatment outcome. Med Oral Patol Oral Cir Bucal. 2012;17(2):356–61.
Khalighinejad N, Aminoshariae MR, Aminoshariae A, Kulild JC, Mickel A, Fouad AF. Association between Systemic Diseases and Apical Periodontitis. J Endod [Internet]. 2016;42(10):1427–34. Available from: http://dx.doi.org/10.1016/j.joen.2016.07.007
Tomazoli ATP, Endo MS, Pavan NNO. The implications of diabetes mellitus in Endodontics. Dent Press Endod. 2018;8(2):47–52.
Iliescu AA, Earar K, Iliescu MG, Ionel D, Gheorghiu IM, Iliescu A, et al. Chronic Apical Periodontitis and Diabetes Mellitus Relationship in Oral Rehabilitation. Rom J Oral Rehabil. 2019;11(1):71–8.
Segura-Egea JJ, Cabanillas-Balsera D, Jiménez-Sánchez MC, Martín-González J. Endodontics and diabetes: association versus causation. Int Endod J. 2019;52(6):790–802.
Nagendrababu V, Segura-Egea JJ, Fouad AF, Pulikkotil SJ, Dummer PMH. Association between diabetes and the outcome of root canal treatment in adults: an umbrella review. Int Endod J. 2020;53(4):455–66.
Ship JA. Diabetes and oral health: an overview. J Am Dent Assoc [Internet]. 2003;134 Spec N:4S-10S. Available from: http://dx.doi.org/10.14219/jada.archive.2003.0367
This work is licensed under a Creative Commons Attribution-NonCommercial 4.0 International License.